Introduction：Basic information about CAS 31883-05-3|Moricizine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Moricizine |
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| CAS Number | 31883-05-3 | Molecular Weight | 427.51700 |
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| Density | 1.315g/cm3 | Boiling Point | 625ºC at 760 mmHg |
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| Molecular Formula | C22H25N3O4S | Melting Point | / |
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| MSDS | / | Flash Point | 331.8ºC |
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Names
| Name | moricizine |
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| Synonym | More Synonyms |
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Moricizine BiologicalActivity
| Description | Moricizine is an antiarrhythmia agent used primarily for ventricular rhythm disturbances.Target: Sodium ChannelMoricizine is an antiarrhythmia agent used primarily for ventricular rhythm disturbances. Moricizine works by inhibiting the rapid inward sodium current across myocardial cell membranes. Moricizine induced the tonic block of INa with the apparent dissociation constant (Kd,app) of 6.3 microM at -100 mV and 99.3 microM at -140 mV. Moricizine at 30 microM shifted the h infinity curve to the hyperpolarizing direction by 8.6 +/- 2.4 mV. Moricizine also produced the phasic block of INa, which was enhanced with the increase in the duration of train pulses, and was more prominent with a holding potential (HP) of -100 mV than with an HP of -140 mV. Moricizine would exert an antiarrhythmic action on atrial myocytes, as well as on ventricular myocytes, by blocking Na+ channels with a high affinity to the inactivated state and a slow dissociation kinetics [1]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>Cardiovascular Disease |
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| References | [1]. Ahmmed, G.U., et al., Analysis of moricizine block of sodium current in isolated guinea-pig atrial myocytes. Atrioventricular difference of moricizine block. Vascul Pharmacol, 2002. 38(3): p. 131-41. |
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Chemical & Physical Properties
| Density | 1.315g/cm3 |
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| Boiling Point | 625ºC at 760 mmHg |
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| Molecular Formula | C22H25N3O4S |
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| Molecular Weight | 427.51700 |
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| Flash Point | 331.8ºC |
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| Exact Mass | 427.15700 |
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| PSA | 96.41000 |
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| LogP | 4.18250 |
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| Index of Refraction | 1.639 |
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| InChIKey | FUBVWMNBEHXPSU-UHFFFAOYSA-N |
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| SMILES | CCOC(=O)Nc1ccc2c(c1)N(C(=O)CCN1CCOCC1)c1ccccc1S2 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- FC9045000
- CHEMICAL NAME :
- Carbamic acid, (10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin- 2-yl)-, ethyl ester
- CAS REGISTRY NUMBER :
- 31883-05-3
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C22-H25-N3-O4-S
- MOLECULAR WEIGHT :
- 427.56
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 11 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5116974
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Moracizin |
| Moracizina [INN-Spanish] |
| Moracizinum |
| ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate |
| Moracizine |
| Moracizina |
| Ethmozin |
| [10-(3-morpholin-4-yl-propionyl)-10H-phenothiazin-2-yl]-carbamic acid ethyl ester |
| Ethmozine |
| Etmozin |
| MORICIZINE |
| Moracizinum [INN-Latin] |
| EINECS 250-854-5 |
