Introduction：Basic information about CAS 163655-37-6|MAZ51, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | MAZ51 |
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| CAS Number | 163655-37-6 | Molecular Weight | 314.380 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 553.9±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H18N2O | Melting Point | / |
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| MSDS | / | Flash Point | 288.8±30.1 °C |
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Names
| Name | maz51 |
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| Synonym | More Synonyms |
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MAZ51 BiologicalActivity
| Description | MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. MAZ51 inhibits VEGF-C-induced activation of VEGFR-3 without blocking VEGF-C-mediated stimulation of VEGFR2. MAZ51 had no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ. MAZ51 blocks proliferation and induces apoptosis in a wide variety of tumor cells. Antitumor activity[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Protein Tyrosine Kinase/RTK >>VEGFR |
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| Target | VEGFR3 |
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| In Vitro | MAZ51 (2.5-10 μM; 24 hours) blocks proliferation and induces apoptosis in a wide variety of tumor cells[2]. MAZ51 (0.5-50 μM; 25 minutes) has no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ in A431 cells, HEK-293 cells, and PAE cells, respectively[2]. Cell Proliferation Assay[2] Cell Line: MT450, 1AS, ASM, G, AT6.1, MTLN3, MTLY, NM-081 cells Concentration: 2.5, 10 μM Incubation Time: 24 hours Result: Induced apoptosis in a wide variety of tumor cells. Apoptosis Analysis[2] Cell Line: MT450, 1AS, ASM, G, AT6.1, MTLN3, MTLY, NM-081 cells Concentration: 2.5, 10 μM Incubation Time: 24 hours Result: Blocked proliferation in a wide variety of tumor cells. |
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| In Vivo | MAZ51 (8 mg/kg; i.p.; daily for 15 day) significantly suppresses the growth of MT450 tumors[2]. Animal Model: Wistar Furth rats (bearing MT450 cells)[1] Dosage: 8 mg/kg Administration: Intraperitoneal injection; daily for 15 day Result: Significantly suppressed the growth of MT450 tumors. |
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| References | [1]. Kirkin V, et al. Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2. Eur J Biochem. 2001 Nov;268(21):5530-40. [2]. Kirkin V, et al. MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo. Int J Cancer. 2004 Dec 20;112(6):986-93. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 553.9±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H18N2O |
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| Molecular Weight | 314.380 |
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| Flash Point | 288.8±30.1 °C |
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| Exact Mass | 314.141907 |
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| PSA | 32.34000 |
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| LogP | 5.15 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.729 |
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| InChIKey | VFCXONOPGCDDBQ-AQTBWJFISA-N |
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| SMILES | CN(C)c1ccc(C=C2C(=O)Nc3ccccc32)c2ccccc12 |
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Safety Information
| Hazard Codes | Xn: Harmful;N: Dangerous for the environment; |
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| Risk Phrases | R22 |
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| Safety Phrases | S26 |
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| RIDADR | UN 3077 9/PG 3 |
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| HS Code | 2933790090 |
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Customs
| HS Code | 2933790090 |
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| Summary | 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
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Synonyms
| 2H-Indol-2-one, 3-[[4-(dimethylamino)-1-naphthalenyl]methylene]-1,3-dihydro-, (3Z)- |
| MFCD04036983 |
| 3-(4-dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one |
| (3Z)-3-{[4-(Dimethylamino)-1-naphthyl]methylene}-1,3-dihydro-2H-indol-2-one |
| 3-(4-Dimethylaminonaphthalen-1-ylmethylene)-1,3-dihydroindol-2-one |
