CAS 78613-38-4|Amorolfine hydrochloride

Introduction：Basic information about CAS 78613-38-4|Amorolfine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Amorolfine hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles3
7. Synonyms

Common Name	Amorolfine hydrochloride
CAS Number	78613-38-4	Molecular Weight	353.970
Density	1.234	Boiling Point	78-82°C (9 Torr)
Molecular Formula	C₂₁H₃₆ClNO	Melting Point	/
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS07, GHS09	Signal Word	Warning

Names

Name	amorolfine hydrochloride
Synonym	More Synonyms

Amorolfine hydrochloride BiologicalActivity

Description	Amorolfine hydrochloride is a antifungal reagent.Target: AntifungalAmorolfine is an antifungal showing activity against fungi pathogenic to plants, animals and humans. Amorolfine possesses a broad antifungal spectrum including dermatophytes, yeasts, dimorphic fungi and moulds and is not only fungistatic but fungicidal against most species [1]. At 0.2, 2 and 5 micrograms/ml amorolfine did not have any significant inhibitory or enhancing effect on phagocytosis whether following simultaneous addition of blastospores and drug to the neutrophils, prior treatment of neutrophils for 2 h before addition of blastospores or prior treatment of blastospores for 2 h. Simultaneous addition of amorolfine resulted in a significant increase in killing at all concentrations. This increase was not significantly enhanced by either preincubation of neutrophils or blastospores for 2 h with the drug [2].
Related Catalog	Signaling Pathways >>Anti-infection >>FungalResearch Areas >>Infection
References	[1]. Polak, A., Preclinical data and mode of action of amorolfine. Dermatology, 1992. 184 Suppl 1: p. 3-7. [2]. Richardson, M.D., G.S. Shankland, and C.A. Gray, Effect of amorolfine (Ro 14-4767/002) on in vitro phagocytosis and intracellular killing of Candida albicans by human neutrophils. Mycoses, 1989. 32(5): p. 245-9.

Description

Amorolfine hydrochloride is a antifungal reagent.Target: AntifungalAmorolfine is an antifungal showing activity against fungi pathogenic to plants, animals and humans. Amorolfine possesses a broad antifungal spectrum including dermatophytes, yeasts, dimorphic fungi and moulds and is not only fungistatic but fungicidal against most species [1]. At 0.2, 2 and 5 micrograms/ml amorolfine did not have any significant inhibitory or enhancing effect on phagocytosis whether following simultaneous addition of blastospores and drug to the neutrophils, prior treatment of neutrophils for 2 h before addition of blastospores or prior treatment of blastospores for 2 h. Simultaneous addition of amorolfine resulted in a significant increase in killing at all concentrations. This increase was not significantly enhanced by either preincubation of neutrophils or blastospores for 2 h with the drug [2].

Related Catalog

Signaling Pathways >>Anti-infection >>FungalResearch Areas >>Infection

References

[1]. Polak, A., Preclinical data and mode of action of amorolfine. Dermatology, 1992. 184 Suppl 1: p. 3-7.

[2]. Richardson, M.D., G.S. Shankland, and C.A. Gray, Effect of amorolfine (Ro 14-4767/002) on in vitro phagocytosis and intracellular killing of Candida albicans by human neutrophils. Mycoses, 1989. 32(5): p. 245-9.

Chemical & Physical Properties

Density	1.234
Boiling Point	78-82°C (9 Torr)
Molecular Formula	C₂₁H₃₆ClNO
Molecular Weight	353.970
Exact Mass	353.248535
PSA	12.47000
LogP	5.40190
InChIKey	XZKWIPVTHGWDCF-KUZYQSSXSA-N
SMILES	CCC(C)(C)c1ccc(CC(C)CN2CC(C)OC(C)C2)cc1.Cl
Storage condition	room temp

Safety Information

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H315-H411
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xn
Risk Phrases	R20/21/22
Safety Phrases	26-36
RIDADR	UN 3077 9 / PGIII
HS Code	29411010

Customs

HS Code	29411010

Articles3

The low keratin affinity of efinaconazole contributes to its nail penetration and fungicidal activity in topical onychomycosis treatment.

Antimicrob. Agents Chemother. 58(7) , 3837-42, (2014)

Onychomycosis is a common fungal nail disease that is difficult to treat topically due to the deep location of the infection under the densely keratinized nail plate. Keratin affinity of topical drugs...

Characterization of Antifungal Activity and Nail Penetration of ME1111, a New Antifungal Agent for Topical Treatment of Onychomycosis.

Antimicrob. Agents Chemother. 60 , 1035-9, (2016)

Fungal nail infection (onychomycosis) is a prevalent disease in many areas of the world, with a high incidence approaching 23%. Available antifungals to treat the disease suffer from a number of disad...

Mechanism of Action of ME1111, a Novel Antifungal Agent for Topical Treatment of Onychomycosis.

Antimicrob. Agents Chemother. 60 , 873-80, (2016)

Despite the existing treatment options for onychomycosis, there remains a strong demand for potent topical medications. ME1111 is a novel antifungal agent that is active against dermatophytes, has an ...

Synonyms

(2R,6S)-2,6-Dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine hydrochloride (1:1)

Loceryl

Locetar

Amorolfine Hydrochloride

(2R,6S)-2,6-Dimethyl-4-{2-methyl-3-[4-(2-methyl-2-butanyl)phenyl]propyl}morpholine hydrochloride (1:1)

MFCD00903738

Curanail

Amorolfine HCl

Odenil

Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, (2R,6S)-, hydrochloride (1:1)

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