CAS 136468-36-5|Foropafant
| Common Name | Foropafant | ||
|---|---|---|---|
| CAS Number | 136468-36-5 | Molecular Weight | 464.70900 |
| Density | 1.065g/cm3 | Boiling Point | 571.6ºC at 760mmHg |
| Molecular Formula | C28H40N4S | Melting Point | / |
| MSDS | USA | Flash Point | 299.5ºC |
Names
| Name | N,N-dimethyl-N'-(pyridin-3-ylmethyl)-N'-[4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl]ethane-1,2-diamine |
|---|---|
| Synonym | More Synonyms |
Foropafant BiologicalActivity
| Description | Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
| Target | Ki: 57 pM ([3H]PAF binding)[1] |
| References | [1]. Herbert JM, et al. Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther. 1991 Oct;259(1):44-51. |
Chemical & Physical Properties
| Density | 1.065g/cm3 |
|---|---|
| Boiling Point | 571.6ºC at 760mmHg |
| Molecular Formula | C28H40N4S |
| Molecular Weight | 464.70900 |
| Flash Point | 299.5ºC |
| Exact Mass | 464.29700 |
| PSA | 60.50000 |
| LogP | 7.14350 |
| Vapour Pressure | 4.49E-13mmHg at 25°C |
| Index of Refraction | 1.575 |
| InChIKey | VVBFISAUNSXQGZ-UHFFFAOYSA-N |
| SMILES | CC(C)c1cc(C(C)C)c(-c2csc(N(CCN(C)C)Cc3cccnc3)n2)c(C(C)C)c1 |
| Storage condition | -20°C |
Safety Information
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles23
More Articles| Platelet-activating factor (PAF) is not an essential component of the cascade leading to smooth muscle cell proliferation following vascular injury. J. Lipid Mediat. Cell Signal. 12(1) , 49-57, (1995) In order to evaluate the relative importance platelet-activating factor (PAF) in the proliferative process leading to restenosis, the effect of SR 27417, a novel highly potent PAF receptor antagonist,... | |
| Prevention of platelet-activating factor-induced gastrointestinal lesions in rats by the new specific antagonist N-(2-dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisopropylphe nyl) thiazol-2yl]amine. Arzneimittelforschung 46(4) , 407-12, (1996) SR 27417 (CAS 136468-36-5, N-(2-dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisop ropylphenyl) thiazol-2-yl]amine), a highly potent platelet-activating factor (PAF) receptor antagonist, was t... | |
| Role of platelet activating factor in the intestinal epithelial secretory and Chinese hamster ovary cell cytoskeletal responses to cholera toxin. Proc. Natl. Acad. Sci. U. S. A. 91(20) , 9655-8, (1994) With the recent heightened concern about cholera around the world come new questions about the mechanism by which cholera toxin causes diarrhea. Peterson and Ochoa have suggested that prostaglandin sy... |
Synonyms
| MFCD00904759 |
