Introduction：Basic information about CAS 165668-41-7|Indisulam, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Indisulam |
|---|
| CAS Number | 165668-41-7 | Molecular Weight | 385.846 |
|---|
| Density | 1.7±0.1 g/cm3 | Boiling Point | 668.9±65.0 °C at 760 mmHg |
|---|
| Molecular Formula | C14H12ClN3O4S2 | Melting Point | / |
|---|
| MSDS | ChineseUSA | Flash Point | 358.4±34.3 °C |
|---|
| Symbol |
GHS07 | Signal Word | Warning |
|---|
Names
| Name | 4-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide |
|---|
| Synonym | More Synonyms |
|---|
Indisulam BiologicalActivity
| Description | Indisulam (E 7070) is a carbonic anhydrase inhibitor and a G1-targeting agent. Indisulam causes a blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 (CDK2) and cyclin E. Shows anti-tumor activity in human colon and lung cancer cells[1][2]. |
|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>Carbonic Anhydrase |
|---|
| Target | Carbonic anhydrase[1]. |
|---|
| References | [1]. Ozawa Y, et al. E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo. Eur J Cancer. 2001 Nov;37(17):2275-82. [2]. Abbate F, et al. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett. 2004 Jan 5;14(1):217-23. |
|---|
Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
|---|
| Boiling Point | 668.9±65.0 °C at 760 mmHg |
|---|
| Molecular Formula | C14H12ClN3O4S2 |
|---|
| Molecular Weight | 385.846 |
|---|
| Flash Point | 358.4±34.3 °C |
|---|
| Exact Mass | 384.995789 |
|---|
| PSA | 138.88000 |
|---|
| LogP | 2.08 |
|---|
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
|---|
| Index of Refraction | 1.731 |
|---|
| InChIKey | SETFNECMODOHTO-UHFFFAOYSA-N |
|---|
| SMILES | NS(=O)(=O)c1ccc(S(=O)(=O)Nc2cccc3c(Cl)c[nH]c23)cc1 |
|---|
| Storage condition | 2-8℃ |
|---|
Safety Information
| Symbol |
GHS07 |
|---|
| Signal Word | Warning |
|---|
| Hazard Statements | H315-H319 |
|---|
| Precautionary Statements | P305 + P351 + P338 |
|---|
| RIDADR | NONH for all modes of transport |
|---|
| HS Code | 2935009090 |
|---|
Customs
| HS Code | 2935009090 |
|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
|---|
Synonyms
| E7070 |
| Indisulam (IND) |
| 1,4-Benzenedisulfonamide, N-(3-chloro-1H-indol-7-yl)- |
| indisulam |
| N-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide |
| N-(3-Chloro-1H-indol-7-yl)benzene-1,4-disulfonamide |
| Indisulam (USAN/INN) |
| 1,4-Benzenedisulfonamide,N-(3-chloro-1H-indol-7-yl) |
