Introduction：Basic information about CAS 3131-03-1|Virginiamycin B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Virginiamycin B |
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| CAS Number | 3131-03-1 | Molecular Weight | 866.95800 |
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| Density | 1.38g/cm3 | Boiling Point | 1202.1ºC at 760mmHg |
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| Molecular Formula | C45H54N8O10 | Melting Point | / |
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| MSDS | / | Flash Point | 680.8ºC |
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Names
| Name | pristinamycin IA |
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| Synonym | More Synonyms |
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Virginiamycin B BiologicalActivity
| Description | Pristinamycin IA is a cyclo-peptidic macrolactone antibiotic belonging to the streptogramin family, a substrate for the P-glycoprotein.In vitro: Pristinamycin IA specifically inhibits the efflux of the P-glycoprotein substrate [3H]vinblastine, thus increasing the cellular accumulation of the drug. Pristinamycin IA also reduces by 70% the basolateral to apical secretion of [3H]vinblastine across Caco-2 cell monolayers. The cellular accumulation of [14C]pristinamycin IA is very low and is increased by P-glycoprotein inhibitors (verapamil, chlorpromazine and reserpine). The basolateral to apical transport of [14C]pristinamycin IA is 100-fold higher than apical to basolateral passage. [1] |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>OthersPeptides |
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| References | [1]. Phung-Ba V et al. Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells. Eur J Pharmacol. 1995 Jan 16;288(2):187-92. |
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Chemical & Physical Properties
| Density | 1.38g/cm3 |
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| Boiling Point | 1202.1ºC at 760mmHg |
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| Molecular Formula | C45H54N8O10 |
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| Molecular Weight | 866.95800 |
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| Flash Point | 680.8ºC |
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| Exact Mass | 866.39600 |
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| PSA | 227.96000 |
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| LogP | 2.13220 |
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| InChIKey | YGXCETJZBDTKRY-QQOZLVKHSA-N |
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| SMILES | CCC1NC(=O)C(NC(=O)c2ncccc2O)C(C)OC(=O)C(c2ccccc2)NC(=O)C2CC(=O)CCN2C(=O)C(Cc2ccc(N(C)C)cc2)N(C)C(=O)C2CCCN2C1=O |
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| Storage condition | -20°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- ZA4870000
- CHEMICAL NAME :
- Virginiamycin S1, 4-(4(dimethylamino)-N-methyl-L-phenylalanine)-
- CAS REGISTRY NUMBER :
- 3131-03-1
- BEILSTEIN REFERENCE NO. :
- 0078387
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C45-H54-N8-O10
- MOLECULAR WEIGHT :
- 867.07
- WISWESSER LINE NOTATION :
- T F5-19-6 ANV DNV JNV MMV QOV TMV A&VTJ C1R DN1&1& D1 L2 P1 SR& OMV- BT6NJ CQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,750,1967
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 350 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,367,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,750,1967
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Safety Information
| RIDADR | UN 3172 |
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| Packaging Group | III |
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| Hazard Class | 6.1(b) |
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Synonyms
| Antibiotic PA 114B |
| Mikamycin B |
| Ostreogrycin B |
| PA 114B |
| Pristinamycin IA |
| Antibiotic PA 114 B1 |
| Vernamycin BA |
| Mikamycin IA |
| Streptogramin B |
