CAS 777-11-7|haloprogin (200 mg)

Introduction:Basic information about CAS 777-11-7|haloprogin (200 mg), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Namehaloprogin (200 mg)
CAS Number777-11-7Molecular Weight361.39100
Density1.959g/cm3Boiling Point391.9ºC at 760 mmHg
Molecular FormulaC9H4Cl3IOMelting Point113-114°
MSDS/Flash Point190.8ºC

Names

Name1,2,4-trichloro-5-(3-iodoprop-2-ynoxy)benzene
SynonymMore Synonyms

haloprogin (200 mg) BiologicalActivity

DescriptionHaloprogin is a potent antifungal agent. Haloprogin has activity against dermatophytes, Candida spp and a limited number of Gram-positive bacteria[1].
Related CatalogResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>Fungal
References

[1]. Harrison EF, et, al. Haloprogin: a topical antifungal agent. Appl Microbiol. 1970 May;19(5):746-50.

Chemical & Physical Properties

Density1.959g/cm3
Boiling Point391.9ºC at 760 mmHg
Melting Point113-114°
Molecular FormulaC9H4Cl3IO
Molecular Weight361.39100
Flash Point190.8ºC
Exact Mass359.83700
PSA9.23000
LogP4.42150
Index of Refraction1.657
InChIKeyCTETYYAZBPJBHE-UHFFFAOYSA-N
SMILESClc1cc(Cl)c(OCC#CI)cc1Cl

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KO1225000
CHEMICAL NAME :
Ether, 3-iodo-2-propynyl 2,4,5-trichlorophenyl
CAS REGISTRY NUMBER :
777-11-7
LAST UPDATED :
199612
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C9-H4-Cl3-I-O
MOLECULAR WEIGHT :
361.38
WISWESSER LINE NOTATION :
I1UU2OR BG DG EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,375,1972
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,375,1972
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Mammal - pig
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,375,1972 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,375,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
152 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,375,1972
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -,569,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
89 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 13,195,1990
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -,569,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,375,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Gastrointestinal - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,375,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1625 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,375,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
137 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,375,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6077 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 314 (estimated)

Safety Information

Hazard CodesXn
Risk Phrases22-36/37/38
Safety Phrases26-36
RTECSKO1225000

Synonyms

2,4,5-Trichlor-phenyl-3-jod-2-propinyl-aether
3-iodo-2-propynyl 2,4,5-trichlorophenyl ether
Mycilan
Haloproginum
Halotex
Mycanden
haloprogin
aloprogen
Haloprogina
Polik
Haloprogine
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