Introduction：Basic information about CAS 135042-17-0|Boc-trans-D-Hyp-OMe, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Boc-trans-D-Hyp-OMe |
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| CAS Number | 135042-17-0 | Molecular Weight | 245.272 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 387.6±42.0 °C at 760 mmHg |
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| Molecular Formula | C11H19NO5 | Melting Point | / |
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| MSDS | / | Flash Point | 188.2±27.9 °C |
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Names
| Name | (2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate |
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| Synonym | More Synonyms |
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Boc-trans-D-Hyp-OMe BiologicalActivity
| Description | Boc-trans-D-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-trans-D-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 387.6±42.0 °C at 760 mmHg |
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| Molecular Formula | C11H19NO5 |
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| Molecular Weight | 245.272 |
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| Flash Point | 188.2±27.9 °C |
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| Exact Mass | 245.126328 |
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| PSA | 76.07000 |
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| LogP | -0.17 |
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| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
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| Index of Refraction | 1.520 |
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| InChIKey | MZMNEDXVUJLQAF-JGVFFNPUSA-N |
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| SMILES | COC(=O)C1CC(O)CN1C(=O)OC(C)(C)C |
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| Storage condition | 2-8°C |
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Safety Information
Synonyms
| 1-O-tert-butyl 2-O-methyl (2R,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate |
| (4S)-4-Hydroxy-2-methyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-proline |
| 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-2-methyl-, 1-(1,1-dimethylethyl) ester, (2R,4S)- |
