Introduction：Basic information about CAS 13602-53-4|Angiotensin III, human, mouse(Acetate), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Angiotensin III, human, mouse(Acetate) |
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| CAS Number | 13602-53-4 | Molecular Weight | 931.09100 |
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| Density | 1.39g/cm3 | Boiling Point | / |
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| Molecular Formula | C46H66N12O9 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | angiotensin iii, human |
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| Synonym | More Synonyms |
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Angiotensin III, human, mouse(Acetate) BiologicalActivity
| Description | Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Angiotensin ReceptorPeptidesResearch Areas >>Cardiovascular Disease |
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| Target | IC50: 0.648 nM (AT2R), 21.1 nM (AT1R)[1] |
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| In Vitro | Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively[1]. |
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| In Vivo | Angiotensin III (7, 14 and 28 nmol/kg/min) increases urine sodium excretion (UNaV), fractional excretion of sodium (FENa), and fractional excretion of lithium (FELi) in SD rat[2]. In RAS (renin-angiotensin system), Angiotensin III increases sympathetic nerve activity and vasopressin release and decreases the baroreflex leading to higher blood pressure in rats[3]. |
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| References | [1]. Bosnyak S, et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci (Lond). 2011 Oct;121(7):297-303. [2]. Kemp BA, et al. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension. 2012 Aug;60(2):387-95. [3]. Gao J, et al. A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors. Clin Sci (Lond). 2014 Aug;127(3):135-48. |
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Chemical & Physical Properties
| Density | 1.39g/cm3 |
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| Molecular Formula | C46H66N12O9 |
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| Molecular Weight | 931.09100 |
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| Exact Mass | 930.50800 |
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| PSA | 339.94000 |
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| LogP | 3.71910 |
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| Index of Refraction | 1.657 |
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| InChIKey | QMMRCKSBBNJCMR-KMZPNFOHSA-N |
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| SMILES | CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(N)CCCN=C(N)N)C(C)C)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)O |
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| Storage condition | −20°C |
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| Water Solubility | H2O: 1.0 mg/mL, clear, colorless |
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Safety Information
Synonyms
| angiotensin I-converting enzyme |
| ACE INACTIVATOR |
| ANGIOTENSIN I-CONVERTING ENZYME INACTIVATOR |
| human AngIII |
| angiotensin III |
| CYANOAC-PHE-PHE-OH |
| H-Arg-Val-Tyr-Ile-His-Pro-Phe-OH |
| CYANOAC-PHE-PHE |
| Angiotensin III, human, mouse |
