Introduction：Basic information about CAS 136790-76-6|Lubiprostone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Lubiprostone |
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| CAS Number | 136790-76-6 | Molecular Weight | 390.462 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 532.3±50.0 °C at 760 mmHg |
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| Molecular Formula | C20H32F2O5 | Melting Point | 56-59ºC |
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| MSDS | ChineseUSA | Flash Point | 275.7±30.1 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | Lubiprostone |
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| Synonym | More Synonyms |
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Lubiprostone BiologicalActivity
| Description | Lubiprostone(SPI-0211;RU0211) is a gastrointestinal agent used for the treatment of idiopathic chronic constipation.Target: OthersLubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM). From Wikipedia. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Chloride ChannelResearch Areas >>Metabolic Disease |
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| References | [1]. http://en.wikipedia.org/wiki/Lubiprostone |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 532.3±50.0 °C at 760 mmHg |
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| Melting Point | 56-59ºC |
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| Molecular Formula | C20H32F2O5 |
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| Molecular Weight | 390.462 |
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| Flash Point | 275.7±30.1 °C |
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| Exact Mass | 390.221771 |
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| PSA | 83.83000 |
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| LogP | 2.85 |
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| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
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| Index of Refraction | 1.486 |
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| Storage condition | -20°C Freezer |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
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| RTECS | UK8257750 |
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| HS Code | 2918990090 |
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Customs
| HS Code | 2918990090 |
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| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| Prostan-1-oic acid, 11,15-epoxy-16,16-difluoro-15-hydroxy-9-oxo-, (11α,15R)- |
| 13,14-dihydro-15-keto-16,16-difluoro-Prostaglandin E1 |
| 9ALPHA-HYDROXY-11,15-DIOXO-PROST-5Z-EN-1-OIC ACID |
| 13,14-dihydro-15-keto Prostaglandin D2 Lipid Maps MS Standard |
| DK-PGD2 |
| (3aR,4R,5R,6aS)-4-[(1E)-4,4-Difluoro-3-oxo-1-octen-1-yl]-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl 4-biphenylcarboxylate |
| 13,14-dihydro-15-keto-prostaglandin D2 |
| [1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-4-[(1E)-4,4-difluoro-3-oxo-1-octen-1-yl]hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester |
| 13,14-Dihydro-15-keto-PGD2 |
| 7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl]heptanoic acid |
| 13,14-Dihydro-15-ketoprostadlandin D2 |
| Lubiprostone |
| (11α,15R)-16,16-Difluoro-15-hydroxy-9-oxo-11,15-epoxyprostan-1-oic acid |
| 13,14-dihydro-15-keto PD2 |
| 13,14-dihydro-15-keto-16,16-difluoro-PGE1 |
