CAS 138530-94-6|Dexlansoprazole

Introduction：Basic information about CAS 138530-94-6|Dexlansoprazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Dexlansoprazole BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Dexlansoprazole
CAS Number	138530-94-6	Molecular Weight	369.362
Density	1.5±0.1 g/cm3	Boiling Point	555.8±60.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₄F₃N₃O₂S	Melting Point	66-68?C
MSDS	/	Flash Point	289.9±32.9 °C

Names

Name	R-(+)-Lansoprazole
Synonym	More Synonyms

Dexlansoprazole BiologicalActivity

Description	(R)-Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid.Target: Proton PumpLansoprazole sodium is sodium salt form of lansoprazole, lansoprazole, a substituted benzimidizole proton pump inhibitor, on pharmacokinetics and metabolism of theophylline has been studied in healthy adults given oral lansoprazole 30 mg once daily for 11 days. On Days 4 and 11 of 300 mg aminophylline was simultaneously administered orally and blood samples for theophylline analysis were taken over 24 h [1]. Patients in the lansoprazole group were significantly less likely to have a recurrence of ulcer complications than patients in the placebo group (P=0.008). There was no significant difference in mortality between the two groups [2]. lansoprazole (AG-1749) and omeprazole, were found to have significant activities against this organism. The activity of lansoprazole was comparable to that of bismuth citrate, with MICs ranging from 3.13 to 12.5 micrograms/ml, and fourfold more potent than that of omeprazole [3].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>Proton PumpResearch Areas >>Inflammation/Immunology
References	[1]. Kokufu, T., et al., Effects of lansoprazole on pharmacokinetics and metabolism of theophylline. Eur J Clin Pharmacol, 1995. 48(5): p. 391-5. [2]. Lai, K.C., et al., Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. N Engl J Med, 2002. 346(26): p. 2033-8. [3]. Iwahi, T., et al., Lansoprazole, a novel benzimidazole proton pump inhibitor, and its related compounds have selective activity against Helicobacter pylori. Antimicrob Agents Chemother, 1991. 35(3): p. 490-6.

Description

(R)-Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid.Target: Proton PumpLansoprazole sodium is sodium salt form of lansoprazole, lansoprazole, a substituted benzimidizole proton pump inhibitor, on pharmacokinetics and metabolism of theophylline has been studied in healthy adults given oral lansoprazole 30 mg once daily for 11 days. On Days 4 and 11 of 300 mg aminophylline was simultaneously administered orally and blood samples for theophylline analysis were taken over 24 h [1]. Patients in the lansoprazole group were significantly less likely to have a recurrence of ulcer complications than patients in the placebo group (P=0.008). There was no significant difference in mortality between the two groups [2]. lansoprazole (AG-1749) and omeprazole, were found to have significant activities against this organism. The activity of lansoprazole was comparable to that of bismuth citrate, with MICs ranging from 3.13 to 12.5 micrograms/ml, and fourfold more potent than that of omeprazole [3].

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>Proton PumpResearch Areas >>Inflammation/Immunology

References

[1]. Kokufu, T., et al., Effects of lansoprazole on pharmacokinetics and metabolism of theophylline. Eur J Clin Pharmacol, 1995. 48(5): p. 391-5.

[2]. Lai, K.C., et al., Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. N Engl J Med, 2002. 346(26): p. 2033-8.

[3]. Iwahi, T., et al., Lansoprazole, a novel benzimidazole proton pump inhibitor, and its related compounds have selective activity against Helicobacter pylori. Antimicrob Agents Chemother, 1991. 35(3): p. 490-6.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	555.8±60.0 °C at 760 mmHg
Melting Point	66-68?C
Molecular Formula	C₁₆H₁₄F₃N₃O₂S
Molecular Weight	369.362
Flash Point	289.9±32.9 °C
Exact Mass	369.075867
PSA	87.08000
LogP	2.76
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.635
InChIKey	MJIHNNLFOKEZEW-RUZDIDTESA-N
SMILES	Cc1c(OCC(F)(F)F)ccnc1CS(=O)c1nc2ccccc2[nH]1
Storage condition	Refrigerator

Safety Information

Hazard Codes	Xi

Synonyms

Dexlansoprazole

1H-Benzimidazole, 2-[(R)-[(1R)-[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-

(R)-2-(3-N,N-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenoxyisobutyrate

2-[(R)-{[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl}sulfinyl]-1H-benzimidazole

R-(+)-Lansoprazole

(+)-Lansoprazole

Dexilant

FESO

(R)-lansoprazole

Kapidex

R-lansoprazole

Lansoprazole Impurity 14

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