CAS 166023-21-8|DC-cholesterol hydrochloride
| Common Name | DC-cholesterol hydrochloride | ||
|---|---|---|---|
| CAS Number | 166023-21-8 | Molecular Weight | 537.26000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C32H57ClN2O2 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Cholest-5-en-3-yl [2-(dimethylamino)ethyl]carbamate hydrochloride (1:1) |
|---|---|
| Synonym | More Synonyms |
DC-cholesterol hydrochloride BiologicalActivity
| Description | DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Neurological Disease |
| References | [1]. Esmail A Elbassal, et al. Effects of Charged Cholesterol Derivatives on Aβ40 Amyloid Formation. J Phys Chem B. 2016 Jan 14;120(1):59-68. [2]. Richard Lantz, et al. Effects of disulfide bond and cholesterol derivatives on human calcitonin amyloid formation. Biopolymers. 2020 May;111(5):e23343. |
Chemical & Physical Properties
| Molecular Formula | C32H57ClN2O2 |
|---|---|
| Molecular Weight | 537.26000 |
| Exact Mass | 536.41100 |
| PSA | 45.06000 |
| LogP | 8.69060 |
| InChIKey | ISXSJGHXHUZXNF-UHFFFAOYSA-N |
| SMILES | CC(C)CCCC(C)C1CCC2C3CC=C4CC(OC(=O)NCCN(C)C)CCC4(C)C3CCC12C.Cl |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles6
More Articles| In vitro liposome-mediated DNA transfection of epithelial cell lines using the cationic liposome DC-Chol/DOPE. Gene Ther. 2 , 603-613, (1995) Clinical trials using cationic liposome-mediated DNA transfer have now been initiated for several disorders including cystic fibrosis. Previous studies have shown that the level of gene expression ach... | |
| Lipofection reagents prepared by a simple ethanol injection technique. Biotechniques 18 , 1027-1032, (1995) Cationic liposomes are being utilized for the delivery of DNA into mammalian cells both in vitro and in vivo. In this report, we describe a rapid, simple injection method for the preparation of cation... | |
| The use of cationic liposomes DC-CHOL/DOPE and DDAB/DOPE for direct transfer of Escherichia coli cytosine deaminase gene into growing melanoma tumors. Gene Ther. 3 , 1026-1031, (1996) An attempt was made to use simple cationic liposomes DC-Chol/DOPE and DDAB/DOPE (DC-Chol is 3 beta (N(N',N-dimethylaminoethane) carbamoyl) cholesterol, DDAB is dimethyldioctadecyl ammonium bromide and... |
Synonyms
| 2,3-dihydroxypropyl dihydrogen phosphate-cyclohexanamine(2:1) |
| DC-cholesterol hydrochloride |
| marinobufotoxin |
| 3β-[N-(Dimethylaminoethane)carbamoyl]cholesterol |
| O-[(N,N-Dimethylaminoethyl)-carbamoyl]cholesterol hydrochloride |
