CAS 132640-22-3|Andolast

Introduction：Basic information about CAS 132640-22-3|Andolast, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Andolast BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Andolast
CAS Number	132640-22-3	Molecular Weight	333.30800
Density	1.551g/cm3	Boiling Point	/
Molecular Formula	C₁₅H₁₁N₉O	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	4-(2H-Tetrazol-5-yl)-N-[4-(2H-tetrazol-5-yl)phenyl]benzamide
Synonym	More Synonyms

Andolast BiologicalActivity

Description	Andolast is an anti-allergic agent for the treatment of bronchial asthma, chronic obstructive pulmonary disease (COPD). Andolast inhibits dose dependently guinea-pig lung cAMP-phosphodiesterase with an IC50 of 50 mM.
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Research Areas >>Inflammation/Immunology
References	[1]. Revel L, Colombo S, Ferrari F, Folco G, Rovati LC, Makovec F. CR 2039, a new bis-(1H-tetrazol-5-yl)phenylbenzamide derivative with potential for the topical treatment of asthma. Eur J Pharmacol. 1992;229(1):45-53. [2]. Czuczwar SJ, Gasior M, Kozicka M, Pietrasiewicz T, Turski WA, Kleinrok Z. A potential anti-asthmatic drug, CR 2039, enhances the anticonvulsive activity of some antiepileptic drugs against pentetrazol in mice. Eur Neuropsychopharmacol. 1998;8(3):233-238.

Description

Andolast is an anti-allergic agent for the treatment of bronchial asthma, chronic obstructive pulmonary disease (COPD). Andolast inhibits dose dependently guinea-pig lung cAMP-phosphodiesterase with an IC50 of 50 mM.

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Research Areas >>Inflammation/Immunology

References

[1]. Revel L, Colombo S, Ferrari F, Folco G, Rovati LC, Makovec F. CR 2039, a new bis-(1H-tetrazol-5-yl)phenylbenzamide derivative with potential for the topical treatment of asthma. Eur J Pharmacol. 1992;229(1):45-53.

[2]. Czuczwar SJ, Gasior M, Kozicka M, Pietrasiewicz T, Turski WA, Kleinrok Z. A potential anti-asthmatic drug, CR 2039, enhances the anticonvulsive activity of some antiepileptic drugs against pentetrazol in mice. Eur Neuropsychopharmacol. 1998;8(3):233-238.

Chemical & Physical Properties

Density	1.551g/cm3
Molecular Formula	C₁₅H₁₁N₉O
Molecular Weight	333.30800
Exact Mass	333.10900
PSA	141.51000
LogP	1.68310
Index of Refraction	1.748
InChIKey	VXEBMQZDPONDFB-UHFFFAOYSA-N
SMILES	O=C(Nc1ccc(-c2nn[nH]n2)cc1)c1ccc(-c2nn[nH]n2)cc1

Synonyms

Benzamide,4-(2H-tetrazol-5-yl)-N-[4-(2H-tetrazol-5-yl)phenyl]

N-4-(5-tetrazolyl)-phenyl-4-(5-tetrazolyl)-benzamide

Andolast

N-4-(5-tetrazolyl)-phenyl-4-(5-tatrazolyl)-benzamide

N-4-(5-tetrazoyl)-phenyl-4-(5-tetrazolyl)-benzamide

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