CAS 1338-43-8|Span 80
Introduction：Basic information about CAS 1338-43-8|Span 80, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Span 80 | ||
|---|---|---|---|
| CAS Number | 1338-43-8 | Molecular Weight | 428.603 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 579.3±50.0 °C at 760 mmHg |
| Molecular Formula | C24H44O6 | Melting Point | 0.986ºC |
| MSDS | ChineseUSA | Flash Point | 186.2±23.6 °C |
Names
| Name | Span 80 |
|---|---|
| Synonym | More Synonyms |
Span 80 BiologicalActivity
| Description | Sorbitan monooleate is a renewable polyol with unique molecular structures for the development and design of bio-based waterborne polyurethane (WPU) with versatility and excellent mechanical properties. Sorbitan monooleate can be used as an excipient, such as nonionic surfactants, emulsifiers. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. Deng H, et al. UV resistance, anticorrosion and high toughness bio-based waterborne polyurethane enabled by a Sorbitan monooleate[J]. Chemical Engineering Journal, 2022, 446: 137124. [2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 579.3±50.0 °C at 760 mmHg |
| Melting Point | 0.986ºC |
| Molecular Formula | C24H44O6 |
| Molecular Weight | 428.603 |
| Flash Point | 186.2±23.6 °C |
| Exact Mass | 428.313782 |
| PSA | 96.22000 |
| LogP | 7.14 |
| Vapour Pressure | 0.0±3.6 mmHg at 25°C |
| Index of Refraction | 1.506 |
| InChIKey | NWGKJDSIEKMTRX-WRYXKDNVSA-N |
| SMILES | CCCCCCCCC=CCCCCCCCC(=O)OCC(O)C1OCC(O)C1O |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 254 gm/kg/6W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - pigmented or nucleated red blood cells
MUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 100 ppm
- REFERENCE :
- BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 45,630,1971 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83475 No. of Facilities: 11289 (estimated) No. of Industries: 95 No. of Occupations: 73 No. of Employees: 71826 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83475 No. of Facilities: 14163 (estimated) No. of Industries: 127 No. of Occupations: 106 No. of Employees: 200724 (estimated) No. of Female Employees: 58462 (estimated)
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 100 ppm
- REFERENCE :
- BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 45,630,1971 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83475 No. of Facilities: 11289 (estimated) No. of Industries: 95 No. of Occupations: 73 No. of Employees: 71826 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83475 No. of Facilities: 14163 (estimated) No. of Industries: 127 No. of Occupations: 106 No. of Employees: 200724 (estimated) No. of Female Employees: 58462 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves |
|---|---|
| Hazard Codes | T+ |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
| RTECS | WG2932400 |
| HS Code | 34021300 |
Customs
| HS Code | 34021300 |
|---|
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Synonyms
| Sorbitane monooleate,sorbitan oleate |
| Sorbitan Monooleate |
| armotanmo |
| EINECS 215-665-4 |
| sorgen40 |
| o250 |
| Oleic acid compound with (2R,3R,4S)-2-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol |
| glycomulo |
| montan80 |
| (R)-1-((2S,3R,4S)-3,4-Dihydroxytetrahydrofuran-2-yl)-2-hydroxyethyl oleate |
| ml33f |
| ml55f |
| mo33f |
| (Sorbitan Monooleate) |
| MFCD00080948 |
| ionets80 |
