CAS 39011-90-0|albiflorin

Introduction：Basic information about CAS 39011-90-0|albiflorin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. albiflorin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles41
6. Synonyms

Common Name	albiflorin
CAS Number	39011-90-0	Molecular Weight	480.462
Density	1.6±0.1 g/cm3	Boiling Point	722.1±60.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₈O₁₁	Melting Point	/
MSDS	USA	Flash Point	248.9±26.4 °C

Names

Name	Albiflorin
Synonym	More Synonyms

albiflorin BiologicalActivity

Description	Albiflorin is a major constituent contained in peony root; possesses therapeutic potential for neurodegenerative diseases.IC50 value:Target: in vitro: Albiflorin significantly ameliorated Glu-induced reduction of cell viability, nuclear and mitochondrial apoptotic alteration, reactive oxygen species accumulation, and B-cell lymphoma 2 (Bcl-2)/Bax ratio. Albiflorin also enhanced phosphorylation of AKT and its downstream element glycogen synthase kinase-3β, and this effect was abrogated by the AKT inhibitor LY294002 [1]. in vivo: Mice were exposed to X-ray radiation (400 Roentgen), and both mice and rabbits were intraperitoneally injected with cyclophosphamide (100.0 mg/kg) and cytarabine chloride (92.7 mg/kg), respectively, for 3 days to induce myelosuppression. Albiflorin was subsequently administrated intravenously at low (15.0 mg/kg for mice, 6.00 mg/kg for rabbits), intermediate (30.0 mg/kg for mice, 12.0 mg/kg for rabbits) and high (60.0 mg/kg for mice, 24.0 mg/kg for rabbits) doses, as well as orally (60.0 mg/kg for mice, 24.0 mg/kg for rabbits) for 7 days. Shenqi tablets were used as positive controls (oral administration of 936.0 mg/kg for mice, 336.0 mg/kg for rabbits). The administration of Albiflorin significantly ameliorated myelosuppression in all cases [2].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/ImmunologyNatural Products >>Terpenoids and Glycosides
References	[1]. Wang D, et al. Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells. J Mol Neurosci. 2013 Oct;51(2):581-90. [2]. Xu W, et al. Therapeutic effects of combination of paeoniflorin and albiflorin from Paeonia radix on radiation and chemotherapy-induced myelosuppression in mice and rabbits. Asian Pac J Cancer Prev. 2011;12(8):2031-7.

Description

Albiflorin is a major constituent contained in peony root; possesses therapeutic potential for neurodegenerative diseases.IC50 value:Target: in vitro: Albiflorin significantly ameliorated Glu-induced reduction of cell viability, nuclear and mitochondrial apoptotic alteration, reactive oxygen species accumulation, and B-cell lymphoma 2 (Bcl-2)/Bax ratio. Albiflorin also enhanced phosphorylation of AKT and its downstream element glycogen synthase kinase-3β, and this effect was abrogated by the AKT inhibitor LY294002 [1]. in vivo: Mice were exposed to X-ray radiation (400 Roentgen), and both mice and rabbits were intraperitoneally injected with cyclophosphamide (100.0 mg/kg) and cytarabine chloride (92.7 mg/kg), respectively, for 3 days to induce myelosuppression. Albiflorin was subsequently administrated intravenously at low (15.0 mg/kg for mice, 6.00 mg/kg for rabbits), intermediate (30.0 mg/kg for mice, 12.0 mg/kg for rabbits) and high (60.0 mg/kg for mice, 24.0 mg/kg for rabbits) doses, as well as orally (60.0 mg/kg for mice, 24.0 mg/kg for rabbits) for 7 days. Shenqi tablets were used as positive controls (oral administration of 936.0 mg/kg for mice, 336.0 mg/kg for rabbits). The administration of Albiflorin significantly ameliorated myelosuppression in all cases [2].

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/ImmunologyNatural Products >>Terpenoids and Glycosides

References

[1]. Wang D, et al. Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells. J Mol Neurosci. 2013 Oct;51(2):581-90.

[2]. Xu W, et al. Therapeutic effects of combination of paeoniflorin and albiflorin from Paeonia radix on radiation and chemotherapy-induced myelosuppression in mice and rabbits. Asian Pac J Cancer Prev. 2011;12(8):2031-7.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	722.1±60.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₈O₁₁
Molecular Weight	480.462
Flash Point	248.9±26.4 °C
Exact Mass	480.163147
PSA	172.21000
LogP	-0.97
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.662
InChIKey	QQUHMASGPODSIW-ICECTASOSA-N
SMILES	CC12CC(O)C3CC1(OC1OC(CO)C(O)C(O)C1O)C3(COC(=O)c1ccccc1)C(=O)O2
Storage condition	?20°C

Safety Information

Safety Phrases	24/25
RIDADR	NONH for all modes of transport

Articles41

Anti-adipogenic and antioxidant effects of the traditional Korean herbal formula Samchulgeonbi-tang: an in vitro study.

Int. J. Clin. Exp. Med. 8 , 8698-708, (2015)

Here we report in vitro anti-adipogenic and antioxidant effects of Samchulgeonbi-tang (SCGBT), a traditional Korean herbal formula.3T3-L1 preadipocytes were differentiated into adipocytes with or with...

Anti-inflammatory actions of herbal formula Gyejibokryeong-hwan regulated by inhibiting chemokine production and STAT1 activation in HaCaT cells.

Biol. Pharm. Bull. 38(3) , 425-34, (2015)

Gyejibokryeong-hwan (GJBRH; Keishi-bukuryo-gan in Japan and Guizhi Fuling Wan in China) is a traditional herbal formula comprising five medicinal herbs and is used to treat climacteric syndrome. GJBRH...

Detection of paeoniflorin and albiflorin by immunostaining technique using anti-paeoniflorin monoclonal antibody.

Phytochem. Anal. 24(2) , 124-8, (2013)

Paeoniae radix is one of the most important crude drugs used in Kampo medicines (KMs). A part of its pharmaceutical properties is due to the presence of paeoniflorin (PF) and albiflorin (AF).For the s...

Synonyms

7-Oxatricyclo[4.3.0.0]nonan-8-one, 9-[(benzoyloxy)methyl]-1-(β-D-glucopyranosyloxy)-4-hydroxy-6-methyl-, (1R,3R,4R,6S,9S)-

[(1R,3R,4R,6S,9S)-1-(β-D-Glucopyranosyloxy)-4-hydroxy-6-methyl-8-oxo-7-oxatricyclo[4.3.0.0]non-9-yl]methyl benzoate

Paeonia lactiflora Pall.

Alibiflorin

albiflorin

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