CAS 39012-20-9|Picroside II

Introduction：Basic information about CAS 39012-20-9|Picroside II, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Picroside II BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Picroside II
CAS Number	39012-20-9	Molecular Weight	512.461
Density	1.7±0.1 g/cm3	Boiling Point	780.8±60.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₈O₁₃	Melting Point	/
MSDS	USA	Flash Point	267.9±26.4 °C

Names

Name	Picroside II
Synonym	More Synonyms

Picroside II BiologicalActivity

Description	Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways[1]. Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury[2].
Related Catalog	Signaling Pathways >>Protein Tyrosine Kinase/RTK >>ROSResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease
References	[1]. Huang Y, et al. Picroside II protects against sepsis via suppressing inflammation in mice. Am J Transl Res. 2016 Dec 15;8(12):5519-5531. eCollection 2016. [2]. Zhai L, et al. Picroside II protects the blood-brain barrier by inhibiting the oxidative signaling pathway in cerebral ischemia-reperfusion injury. PLoS One. 2017 Apr 7;12(4):e0174414.

Description

Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and NF-κB pathways[1]. Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury[2].

Related Catalog

Signaling Pathways >>Protein Tyrosine Kinase/RTK >>ROSResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease

References

[1]. Huang Y, et al. Picroside II protects against sepsis via suppressing inflammation in mice. Am J Transl Res. 2016 Dec 15;8(12):5519-5531. eCollection 2016.

[2]. Zhai L, et al. Picroside II protects the blood-brain barrier by inhibiting the oxidative signaling pathway in cerebral ischemia-reperfusion injury. PLoS One. 2017 Apr 7;12(4):e0174414.

Chemical & Physical Properties

Density	1.7±0.1 g/cm3
Boiling Point	780.8±60.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₈O₁₃
Molecular Weight	512.461
Flash Point	267.9±26.4 °C
Exact Mass	512.153015
PSA	197.13000
LogP	-2.50
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.681
InChIKey	AKNILCMFRRDTEY-MRFBWRKESA-N
SMILES	COc1cc(C(=O)OC2C3C=COC(OC4OC(CO)C(O)C(O)C4O)C3C3(CO)OC23)ccc1O
Storage condition	2-8°C
Water Solubility	ethanol: soluble1mg/mL, clear, colorless

Safety Information

Hazard Codes	Xi
Safety Phrases	24/25
RIDADR	NONH for all modes of transport

Synonyms

AMPHICOSIDE

Amphicoside II

PicrosideII

Vanilloyl catalpol

Picroside-2

6'-VANILLOYL CATALPOL

2-(Hexopyranosyloxy)-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-6-yl 4-hydroxy-3-methoxybenzoate

PICROSID II

Benzoic acid, 4-hydroxy-3-methoxy-, 2-(hexopyranosyloxy)-1a,1b,2,5a,6,6a-hexahydro-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-6-yl ester

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