CAS 18797-79-0|(+)-Corynoline

Introduction：Basic information about CAS 18797-79-0|(+)-Corynoline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (+)-Corynoline BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	(+)-Corynoline
CAS Number	18797-79-0	Molecular Weight	367.395
Density	1.4±0.1 g/cm3	Boiling Point	504.2±50.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₁NO₅	Melting Point	217-218ºC
MSDS	ChineseUSA	Flash Point	258.7±30.1 °C
Symbol	GHS06	Signal Word	Danger

Names

Name	Corynoline
Synonym	More Synonyms

(+)-Corynoline BiologicalActivity

Description	Corynoline, isolated from Corydalis incise (Papaveraceae), is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].
Related Catalog	Signaling Pathways >>NF-κB >>Keap1-Nrf2Research Areas >>Inflammation/ImmunologyResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>AChE
References	[1]. Kim DK. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res. 2002 Dec;25(6):817-9. [2]. Liu B, et al. Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS)-Stimulated Human Umbilical Vein Endothelial Cells through Activating Nrf2. Inflammation. 2018 Oct;41(5):1640-1647.

Description

Corynoline, isolated from Corydalis incise (Papaveraceae), is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].

Related Catalog

Signaling Pathways >>NF-κB >>Keap1-Nrf2Research Areas >>Inflammation/ImmunologyResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>AChE

References

[1]. Kim DK. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res. 2002 Dec;25(6):817-9.

[2]. Liu B, et al. Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS)-Stimulated Human Umbilical Vein Endothelial Cells through Activating Nrf2. Inflammation. 2018 Oct;41(5):1640-1647.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	504.2±50.0 °C at 760 mmHg
Melting Point	217-218ºC
Molecular Formula	C₂₁H₂₁NO₅
Molecular Weight	367.395
Flash Point	258.7±30.1 °C
Exact Mass	367.141968
PSA	60.39000
LogP	3.23
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.659

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300 + H330
Precautionary Statements	P260-P284-P301 + P310 + P330-P304 + P340 + P310-P403 + P233
Hazard Codes	Xi
Safety Phrases	24/25
RIDADR	UN 1544PSN1 6.1 / PGII

Synonyms

(11S,13R,14R)-corynoline

13-Methylchelidonine

13-methyl-chelidonine

Corynoline

[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol, 5b,6,7,12b,13,14-hexahydro-5b,13-dimethyl-, (5bR,6S,12bR)-

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