Introduction：Basic information about CAS 478-61-5|d-berbamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | d-berbamine |
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| CAS Number | 478-61-5 | Molecular Weight | 608.723 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 707.0±60.0 °C at 760 mmHg |
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| Molecular Formula | C37H40N2O6 | Melting Point | 225°C |
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| MSDS | / | Flash Point | 381.4±32.9 °C |
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Names
| Name | berbamine |
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| Synonym | More Synonyms |
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d-berbamine BiologicalActivity
| Description | Berbamine is a natural compound extracted from traditional Chinese medicine Barberry with anti-tumor, immunomodulatory and cardiovascular effects. Berbamine is a calcium channel blocker. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Autophagy >>Autophagy |
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| Target | NF-κB |
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| References | [1]. Liang Y, et al. Berbamine, a novel nuclear factor kappaB inhibitor, inhibits growth and induces apoptosis in human myeloma cells. Acta Pharmacol Sin. 2009 Dec;30(12):1659-65. [2]. Meng Z, et al. Berbamine inhibits the growth of liver cancer cells and cancer-initiating cells by targeting Ca2+/calmodulin-dependent protein kinase II. Mol Cancer Ther. 2013 Oct;12(10):2067-77. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 707.0±60.0 °C at 760 mmHg |
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| Melting Point | 225°C |
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| Molecular Formula | C37H40N2O6 |
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| Molecular Weight | 608.723 |
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| Flash Point | 381.4±32.9 °C |
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| Exact Mass | 608.288635 |
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| PSA | 72.86000 |
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| LogP | 3.89 |
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| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
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| Index of Refraction | 1.602 |
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| InChIKey | DFOCUWZXJBAUSQ-UHFFFAOYSA-N |
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| SMILES | COc1cc2c3cc1Oc1c(OC)c(OC)cc4c1C(Cc1ccc(O)c(c1)Oc1ccc(cc1)CC3N(C)CC2)N(C)CC4 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DR9450000
- CHEMICAL NAME :
- Berbamine
- CAS REGISTRY NUMBER :
- 478-61-5
- BEILSTEIN REFERENCE NO. :
- 0078902
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C37-H40-N2-O6
- MOLECULAR WEIGHT :
- 608.79
- WISWESSER LINE NOTATION :
- T-T66 CNT&J C1 HO1 IO- JT66 CNT&J C1 HO1 IO1 B1R DQ COR D1- B-18-J
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,26,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 14,45,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,2413,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 17430 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 14,45,1983
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
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| Safety Phrases | S26-S36 |
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Synonyms
| 6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-ol |
| MFCD00067632 |
| E6 berbamine |
| BERBAMAN-12-OL,6,6',7-TRIMETHOXY-2,2'-DIMETHYL |
| 6,7,6'-trimethoxy-2,2'-dimethyl-berbaman-12-ol |
| EINECS 207-523-5 |
| d-berbamine |
| BERBAINE |
| Berbaman-12-ol, 6,6',7-trimethoxy-2,2'-dimethyl- |
| berberamine |
