Introduction：Basic information about CAS 136-16-3|Oxythiamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Oxythiamine |
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| CAS Number | 136-16-3 | Molecular Weight | 266.34 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C12H16N3O2S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Oxythiamine Chloride |
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| Synonym | More Synonyms |
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Oxythiamine BiologicalActivity
| Description | Oxythiamine, an antimetabolite and a vitamin B1 antagonist, is a well-known thiamine antagonist and inhibitor of transketolase. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Cancer |
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| Target | Vitamin B1, Thiamine, Transketolase[1]. |
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| In Vitro | Oxythiamine, an antimetabolite and a vitamin B1 antagonist, is a well-known thiamine antagonist and inhibitor of transketolase. Oxythiamine alters protein expression in a dose dependent manner. The level of alpha-enolase is increased by Oxythiamine treatment, while expression of 14-3-3 protein beta/alpha is suppressed by Oxythiamine at a stratified dose. Oxythiamine causes dynamic changes of total protein expression in time dependent fashion. Oxythiamine suppresses expression of cellular phosphor proteins significantly[2]. |
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| Cell Assay | Human pancreatic carcinoma cell line MIA PaCa-2 is used throughout the study. Experiments are set up in two groups: dose and time-dependent groups. For the dose-dependent group, the cells are stimulated with 5, 50 and 500 μM Oxythiamine (OT) for 48 hours, respectively. The unstimulated cells are considered as control. For the time-dependent group, the cells are stimulated with 50 μM Oxythiamine in MEM containing natural amino acids or 50% of 15 N algal amino acid mixture for 12 and 48 h. The unstimulated cells are considered as the zero time point. Each treatment is repeated four times with 10 mL/flask. The cell pellets are then collected for further analysis[2]. |
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| References | [1]. Moradi H, et al. Functional thiamine deficiency in end-stage renal disease: malnutrition despite ample nutrients. Kidney Int. 2016 Aug;90(2):252-254. [2]. Wang J, et al. Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells. Exp Hematol Oncol. 2013 Jul 27;2:18. |
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Chemical & Physical Properties
| Molecular Formula | C12H16N3O2S |
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| Molecular Weight | 266.34 |
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| PSA | 98.36000 |
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| LogP | 2.33510 |
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| InChIKey | SRDGSXVLAVRBLU-UHFFFAOYSA-O |
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| SMILES | Cc1ncc(C[n+]2csc(CCO)c2C)c(=O)[nH]1 |
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| Storage condition | 2-8℃ |
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Synonyms
| Oxythiamine HCl |
| 5-[[5-(2-Hydroxyethyl)-4-Methyl-Thiazol-3-ium-3-yl]Methyl]-2-Methyl-3H-Pyrimidin-4-One Chloride |
| 5-[[5-(2-Hydroxyethyl)-4-Methyl-3-Thiazol-3-iumyl]Methyl]-2-Methyl-3H-Pyrimidin-4-One Chloride |
| 3-[(3,4-Dihydro-2-Methyl-4-Oxo-5-Pyrimidinyl)Methyl]-5-(2-Hydroxyethyl)-4-Methyl-Thiazolium |
| 5-[2-Hydroxyethyl]-3-[4-hydroxy-2-methyl-5-pyrimidinylmethyl]-4-methylthiazolium chloride hydrochloride |
