Introduction：Basic information about CAS 39219-28-8|Promestriene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Promestriene |
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| CAS Number | 39219-28-8 | Molecular Weight | 328.488 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 436.8±45.0 °C at 760 mmHg |
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| Molecular Formula | C22H32O2 | Melting Point | 64-660ºC |
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| MSDS | / | Flash Point | 153.3±28.3 °C |
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Names
| Name | Promestriene |
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| Synonym | More Synonyms |
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Promestriene BiologicalActivity
| Description | Promestriene is a synthetic diethyl-ether of estradiol and a locally effective estrogen. Promestriene has an efficient action on vaginal atrophy while it is minimally absorbed[1][2]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>EndocrinologySignaling Pathways >>Others >>Others |
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| In Vitro | Promestriene is an analogue of oestradiol which is minimally absorbed and devoid of systemic effects when administered intravaginally, either as gynecological cream or capsules[2]. Topical Promestriene is minimally absorbed with chronic use and has been reported to significantly improve the symptoms of vaginal atrophy[3]. |
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| References | [1]. Isabel Santos, et al. Urogenital Disorders Associated With Oestrogen Deficiency: The Role of Promestriene as Topical Oestrogen Therapy. Gynecol Endocrinol. 2010 Sep;26(9):644-51. [2]. Lino Del Pup, et al. Promestriene, a Specific Topic Estrogen. Review of 40 Years of Vaginal Atrophy Treatment: Is It Safe Even in Cancer Patients. Anticancer Drugs. 2013 Nov;24(10):989-98. [3]. AJO Almodovar, et al. Abstract P5-05-07: Promestriene effects on estrogen-sensitive breast cancer cell proliferation in vitro. Cancer Res 2013;73(24 Suppl): Abstract nr P5-05-07. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 436.8±45.0 °C at 760 mmHg |
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| Melting Point | 64-660ºC |
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| Molecular Formula | C22H32O2 |
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| Molecular Weight | 328.488 |
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| Flash Point | 153.3±28.3 °C |
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| Exact Mass | 328.240234 |
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| PSA | 18.46000 |
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| LogP | 6.48 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.546 |
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| InChIKey | IUWKNLFTJBHTSD-AANPDWTMSA-N |
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| SMILES | CCCOc1ccc2c(c1)CCC1C2CCC2(C)C(OC)CCC12 |
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| Storage condition | -20°C Freezer |
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Synonyms
| 17-Methoxy-3-propoxyestra-1,3,5(10)-triene |
| MFCD00867247 |
| Promestriene |
| EINECS 254-361-6 |
| Promestriene [DCF:INN] |
| Estra-1,3,5(10)-triene, 17-methoxy-3-propoxy- |
| 3-Propoxy-17beta-methoxy-1,3,5(10)-estratriene |
