CAS 310427-94-2|Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (668-67

Introduction：Basic information about CAS 310427-94-2|Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (668-67, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameArg-Glu(EDANS)-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (668-675)-Lys(DABCYL)-Arg trifluoroacetate salt
CAS Number310427-94-2Molecular Weight2005.22
Density/Boiling Point/
Molecular FormulaC91H129N25O25SMelting Point/
MSDS/Flash Point/

Names

NameArg-Glu: EDANS-: Asn670,Leu671-Amyloid b/A4 Protein Precursor770: 668-675-Lys: DABCYL-Arg
SynonymMore Synonyms

BiologicalActivity

DescriptionRE (EDANS) EVNLDAEFK (DABCYL) R is an EDANS and DABCYL double-labeled peptide，serves as a fluorescent substrate for BACE1(Em=360nm，Ex=528nm). RE (EDANS) EVNLDAEFK (DABCYL) R can be used for BACE1 activity measurement and the enzyme activity level is directly proportional to the fluorescence reaction[1].
Related CatalogSignaling Pathways >>Neuronal Signaling >>Beta-secretaseResearch Areas >>Neurological Disease
References

[1]. Ortega A, et.al. Synthesis and evaluation of arylquinones as BACE1 inhibitors, β-amyloid peptide aggregation inhibitors, and destabilizers of preformed β-amyloid fibrils. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2183-7.  

Chemical & Physical Properties

Molecular FormulaC91H129N25O25S
Molecular Weight2005.22
Exact Mass2003.93000
PSA823.15000
LogP8.81010

Safety Information

Safety Phrases22-24/25
WGK Germany3

Synonyms

arg-glu(edans)-glu-val-asn-leu-asp-ala-glu-phe-lys(dabcyl)-arg
h-arg-glu(edans)-glu-val-asn-leu-asp-ala-glu-phe-lys(dabcyl)-arg-oh
arg-glu(edans)-[asn670,leu671]-amyloid b/a4 protein precursor 770 fragment 669-674-(dabcyl)lys-arg
arg-glu(edans)-(asn670,leu671)-app770 (668-675)-lys(dabcyl)-arg
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