Introduction：Basic information about CAS 16142-27-1|Linsidomine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
SIN-1 (chloride) is the active metabolite of molsidomine. SIN-1 (chloride) exhibits potent vasorelaxant effect and inhibition of platelet aggregation[1]. SIN-1 (chloride) decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion[2].
Related Catalog
Research Areas >>Cardiovascular Disease
References
[1]. Nishikawa M,et al. Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites. J Pharmacol Exp Ther. 1982 Jan;220(1):183-90.
[2]. Siegfried MR, et al. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion. J Pharmacol Exp Ther. 1992 Feb;260(2):668-75.
Chemical & Physical Properties
Melting Point
186 °C
Molecular Formula
C6H11ClN4O2
Molecular Weight
206.630
Exact Mass
206.057053
PSA
67.28000
Storage condition
-20°C
Water Solubility
soluble
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
WU7687800
CHEMICAL NAME :
Sydnone imine, 3-morpholino-, monohydrochloride
CAS REGISTRY NUMBER :
16142-27-1
LAST UPDATED :
198910
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C6-H10-N4-O2.Cl-H
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
480 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
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