Introduction：Basic information about CAS 71686-01-6|Calcium 2-oxopentanedioate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Calcium 2-oxopentanedioate |
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| CAS Number | 71686-01-6 | Molecular Weight | 184.160 |
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| Density | / | Boiling Point | 345.6ºC at 760 mmHg |
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| Molecular Formula | C5H4CaO5 | Melting Point | / |
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| MSDS | / | Flash Point | 177ºC |
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Names
| Name | calcium,2-oxopentanedioate |
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| Synonym | More Synonyms |
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Calcium 2-oxopentanedioate BiologicalActivity
| Description | 2-Ketoglutaric acid calcium (Alpha-Ketoglutaric acid calcium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid calcium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid calcium is a reversible inhibitor of tyrosinase (IC50=15 mM)[1][2]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Metabolic Enzyme/Protease >>Tyrosinase |
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| Target | Tyrosinase:15 mM (IC50) Human Endogenous Metabolite |
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| In Vitro | 2-Ketoglutaric acid calcium (Alpha-Ketoglutaric acid calcium) has other physiological capabilities including reduction of ammonia level formed in the lung and general ammonia detoxification, protective role against lipid peroxidation and neuroprotective effect against cyanide poisoning[1]. 2-Ketoglutaric acid calcium acts as precursor for the synthesis of amino acids and nucleotides[2]. |
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| References | [1]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. [2]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662. |
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Chemical & Physical Properties
| Boiling Point | 345.6ºC at 760 mmHg |
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| Molecular Formula | C5H4CaO5 |
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| Molecular Weight | 184.160 |
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| Flash Point | 177ºC |
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| Exact Mass | 183.968460 |
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| PSA | 69.67000 |
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| InChIKey | LADYPAWUSNPKJF-UHFFFAOYSA-L |
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| SMILES | O=C([O-])CCC(=O)C(=O)[O-].[Ca+2] |
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Safety Information
Customs
| HS Code | 2918300090 |
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| Summary | 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| EINECS 275-843-2 |
| Pentanedioic acid, 2-oxo-, calcium salt (1:1) |
| MFCD02683879 |
| calcium 2-oxidanylidenepentanedioate |
| 2-oxo-glutaric acid,calcium salt |
| 2-Oxo-glutarsaeure,Calcium-Salz |
| Calcium 2-oxopentanedioate |
| Calcium 2-oxoglutarate |
