CAS 636-46-4|4-Hydroxyisophthalic acid

Introduction：Basic information about CAS 636-46-4|4-Hydroxyisophthalic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles5
7. Synonyms

Common Name	4-Hydroxyisophthalic acid
CAS Number	636-46-4	Molecular Weight	182.130
Density	1.6±0.1 g/cm3	Boiling Point	447.5±40.0 °C at 760 mmHg
Molecular Formula	C₈H₆O₅	Melting Point	>300°C
MSDS	ChineseUSA	Flash Point	238.6±23.8 °C
Symbol	GHS05, GHS07	Signal Word	Danger

Names

Name	4-Hydroxyisophthalic acid
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	447.5±40.0 °C at 760 mmHg
Melting Point	>300°C
Molecular Formula	C₈H₆O₅
Molecular Weight	182.130
Flash Point	238.6±23.8 °C
Exact Mass	182.021530
PSA	94.83000
LogP	2.09
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.666
InChIKey	BCEQKAQCUWUNML-UHFFFAOYSA-N
SMILES	O=C(O)c1ccc(O)c(C(=O)O)c1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NT2544000

CHEMICAL NAME :: Isophthalic acid, 4-hydroxy-

CAS REGISTRY NUMBER :: 636-46-4

BEILSTEIN REFERENCE NO. :: 2211981

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H6-O5

MOLECULAR WEIGHT :: 182.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1071 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 11,20,1956

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 16,200,1961 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 73500 mg/kg/14W-C

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 11,20,1956

Safety Information

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H318
Precautionary Statements	P280-P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37/39
RIDADR	NONH for all modes of transport
RTECS	NT2544000
HS Code	2918290000

Customs

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles5

A catabolic plasmid involved in 4-methyl-o-phthalate and 4-hydroxy-iso-phthalate degradation in Pseudomonas cepacia.

FEMS Microbiol. Lett. 57(3) , 323-8, (1990)

Genes involved in 4-methyl-o-phthalate and 4-hydroxy-iso-phthalate catabolism reside on a 226-232 kbp catabolic plasmid termed MOP. This was confirmed by transformation and conjugation into an isogeni...

[In vitro study of the mechanism of the platelet anti-aggregant action of picotamide (G 137)].

Boll. Soc. Ital. Biol. Sper. 59(3) , 309-15, (1983)

[In vitro study of the effects of various 4-hydroxyisophthalic acid derivatives on human platelet aggregation].

Boll. Soc. Ital. Biol. Sper. 59(3) , 302-8, (1983)

Synonyms

4-Hydroxyisophthalic acid

MFCD00010391

4-Hydroxy-1,3-benzenedecarboxylic acid

1,3-Benzenedicarboxylic acid, 4-hydroxy-

4-Hydroxybenzene-1,3-dicarboxylic acid

EINECS 211-258-0

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