CAS 135729-56-5|Palonosetron

Introduction：Basic information about CAS 135729-56-5|Palonosetron, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Palonosetron BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Palonosetron
CAS Number	135729-56-5	Molecular Weight	294.39
Density	1.2±0.1 g/cm3	Boiling Point	470.4±45.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₂N₂O	Melting Point	/
MSDS	/	Flash Point	209.5±21.1 °C

Names

Name	Palonosetron
Synonym	More Synonyms

Palonosetron BiologicalActivity

Description	Dehydro Palonosetron (RS 42358-197) is a potent, seslective and orally active 5-HT3 receptor antagonist. Dehydro Palonosetron has no effect on the activities of 5-HT1 receptors, 5-HT2 receptors or 5-HT4 receptors[1].
Related Catalog	Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor
Target	5-HT3 Receptor
References	[1]. R M Eglen, et al. RS 42358-197, a novel and potent 5-HT3 receptor antagonist, in vitro and in vivo. J Pharmacol Exp Ther. 1993 Aug;266(2):535-43. [2]. B Costall, et al. The effect of the 5-HT3 receptor antagonist, RS-42358-197, in animal models of anxiety. Eur J Pharmacol. 1993 Mar 30;234(1):91-9.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	470.4±45.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₂N₂O
Molecular Weight	294.39
Flash Point	209.5±21.1 °C
Exact Mass	296.188873
PSA	23.55000
LogP	2.61
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.646
InChIKey	DIDFYSQVOPVZQB-QGZVFWFLSA-N
SMILES	O=c1c2cccc3c2c(cn1C1CN2CCC1CC2)CCC3

Synonyms

1H-Benz[de]isoquinolin-1-one, 2-(1-azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-

2-(1-Azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one

Palonosteron

2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one

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