CAS 78090-11-6|Picoprazole
Introduction：Basic information about CAS 78090-11-6|Picoprazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Picoprazole | ||
|---|---|---|---|
| CAS Number | 78090-11-6 | Molecular Weight | 343.40000 |
| Density | 1.41g/cm3 | Boiling Point | 597.1ºC at 760 mmHg |
| Molecular Formula | C17H17N3O3S | Melting Point | / |
| MSDS | / | Flash Point | 314.9ºC |
Names
| Name | methyl 6-methyl-2-[(3-methylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole-5-carboxylate |
|---|---|
| Synonym | More Synonyms |
Picoprazole BiologicalActivity
| Description | Picoprazole is a specific inhibitor of H+/K+-ATPase with IC50 of 3.1±0.4 μM. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Proton PumpResearch Areas >>Metabolic Disease |
| Target | IC50: 3.1±0.4 μM (H+/K+-ATPase)[1] |
| In Vitro | Picoprazole inhibits the H+/K+-ATPase activity in a concentration-dependent manner. The IC50 value is 3.1±0.4 μM[1]. Picoprazole is a specific inhibitor of H+/K+-ATPase and binds to 100-kDa polypeptides of the enzyme, dose dependently inhibited opening of the Cl- conductance by Cu2+-o-phenanthroline, indicating that the Cl- conductance is part of the function of the H+/K+-ATPase[2]. The inhibitory effect of the three benzimidazole derivatives Timoprazole, Picoprazole, and Omeprazole on histamine and dbcAMP stimulated 14C-aminopyrine accumulation (H+ secretion) has been studied in isolated and enriched guinea-pig parietal cells. All compounds tested inhibit H+ secretion in a concentration dependent manner with IC50 values of 8.5±1.9 μM for Timoprazole, 3.9±0.7 μM for Picoprazole, and 0.13±0.03 μM for Omeprazole[3]. |
| References | [1]. Beil W, et al. Inhibition of partially purified H+/K+-ATPase from guinea-pig isolated and enriched parietal cells by substituted benzimidazoles. Br J Pharmacol. 1984 Jul;82(3):651-7. [2]. Takeguchi N, et al. Disulfide cross-linking of H,K-ATPase opens Cl- conductance, triggering proton uptake in gastric vesicles. Studies with specific inhibitors. J Biol Chem. 1986 Feb 25;261(6):2560-6. [3]. Sewing KF, et al. Effect of substituted benzimidazoles on acid secretion in isolated and enriched guinea pig parietal cells. Gut. 1983 Jun;24(6):557-60. |
Chemical & Physical Properties
| Density | 1.41g/cm3 |
|---|---|
| Boiling Point | 597.1ºC at 760 mmHg |
| Molecular Formula | C17H17N3O3S |
| Molecular Weight | 343.40000 |
| Flash Point | 314.9ºC |
| Exact Mass | 343.09900 |
| PSA | 104.15000 |
| LogP | 3.53480 |
| Index of Refraction | 1.684 |
| InChIKey | ASSMECARUIRCML-UHFFFAOYSA-N |
| SMILES | COC(=O)c1cc2nc(S(=O)Cc3ncccc3C)[nH]c2cc1C |
| Storage condition | 2-8℃ |
Synonyms
| Picoprazolum |
| methyl 6-methyl-2-[[(3-methyl-2-pyridyl)methyl]sulfinyl]-5-benzimidazolecarboxylate |
| Picoprazol |
| Picoprazole |
| Picoprazole (INN) |
