CAS 65184-10-3|Teoprolol

Introduction：Basic information about CAS 65184-10-3|Teoprolol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Teoprolol BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	Teoprolol
CAS Number	65184-10-3	Molecular Weight	454.52200
Density	1.37g/cm3	Boiling Point	747.6ºC at 760 mmHg
Molecular Formula	C₂₃H₃₀N₆O₄	Melting Point	/
MSDS	/	Flash Point	405.9ºC

Names

Name	7-[3-[[2-hydroxy-3-[(2-methyl-1H-indol-4-yl)oxy]propyl]amino]butyl]-1,3-dimethylpurine-2,6-dione
Synonym	More Synonyms

Teoprolol BiologicalActivity

Description	Teoprolol is a β-adrenergic receptor blocker.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Others
References	[1]. S. D. Yuzhakov, et al. Structure-activity relationships in β-adrenoblockers. Pharmaceutical Chemistry Journal. May 1991, Volume 25, Issue 5, pp 283-295

Chemical & Physical Properties

Density	1.37g/cm3
Boiling Point	747.6ºC at 760 mmHg
Molecular Formula	C₂₃H₃₀N₆O₄
Molecular Weight	454.52200
Flash Point	405.9ºC
Exact Mass	454.23300
PSA	119.10000
LogP	1.42240
Index of Refraction	1.665
InChIKey	HITMZSXZYGLDCV-UHFFFAOYSA-N
SMILES	Cc1cc2c(OCC(O)CNC(C)CCn3cnc4c3c(=O)n(C)c(=O)n4C)cccc2[nH]1
Storage condition	2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO8437700

CHEMICAL NAME :: 1H-Purine-2,6-dione, 3,7-dihydro-7-(3-((2-hydroxy-3-((2-methyl-1H-indol-4- yl)oxy)propyl) amino)butyl)-1,3-dimethyl-

CAS REGISTRY NUMBER :: 65184-10-3

BEILSTEIN REFERENCE NO. :: 1234202

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C23-H30-N6-O4

MOLECULAR WEIGHT :: 454.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1870 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 38 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,825,1982

Synonyms

Teoprololum [INN-Latin]

Teoprolol

1H-Purine-2,6-dione,3,7-dihydro-7-(3-((2-hydroxy-3-((2-methyl-1H-indol-4-yl)oxy)propyl)amino)butyl)-1,3-dimethyl

EINECS 265-600-9

7-{3-[2-hydroxy-3-(2-methyl-indol-4-yloxy)-propylamino]-butyl}-1,3-dimethyl-3,7-dihydro-purine-2,6-dione

7-(3-((2-Hydroxy-3-((2-methylindol-4-yl)oxy)propyl)amino)butyl)theophylline

D-13,312

Teoprololum

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