CAS 636-79-3|3-Pyridinecarboxylicacid, hydrochloride (1:1)
Introduction：Basic information about CAS 636-79-3|3-Pyridinecarboxylicacid, hydrochloride (1:1), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3-Pyridinecarboxylicacid, hydrochloride (1:1) | ||
|---|---|---|---|
| CAS Number | 636-79-3 | Molecular Weight | 159.57000 |
| Density | / | Boiling Point | 292.5ºC at 760 mmHg |
| Molecular Formula | C6H6ClNO2 | Melting Point | 236.6ºC |
| MSDS | / | Flash Point | 130.7ºC |
Names
| Name | pyridine-3-carboxylic acid,hydrochloride |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Cardiovascular DiseaseResearch Areas >>Metabolic Disease |
| Target | Microbial Metabolite |
| In Vitro | Niacin hydrochloride (0-900 μM, 42 hours) significantly increases GSH levels and decreases ROS levels, and affects the expression of genes related to apoptosis and lipid metabolism[1]. Niacin hydrochloride (0-40 μM, 24 hours) can inhibit cancer invasive activity at low dose but with no influence on proliferation[2]. RT-PCR[1] Cell Line: Cumulus cells and oocytes of prepubertal gilts Concentration: 600 μM Incubation Time: 42 hours Result: Up-regulated the relative expression of the anti-apoptotic gene BCL2 and lipid metabolism gene ACACA while down-regulated the pro-apoptotic gene BAX. Cell Proliferation Assay[2] Cell Line: Rat ascites hepatoma cell line of AH109A Concentration: 0-40 μM Incubation Time: 24 hours Result: Had no effect on the proliferation of AH109A cells but suppressed cell invasion from 2.5 μM to 40 μM. |
| In Vivo | Niacin hydrochloride (subcutaneous injection, 3-300 mg/kg, once) can induce vasodilation in a dose-dependent manner within minutes in male C57BL/6 mice[3]. Animal Model: Male C57BL/6 mice[3] Dosage: 3-300 mg/kg Administration: Subcutaneous injection; once Result: Induced vasodilation in a dose-dependent manner. |
| References | [1]. Areeg M Almubarak, et al. Supplementation with Niacin during in vitro maturation improves the quality of porcine embryos. Theriogenology. 2021 Jul 15;169:36-46. doi: 10.1016/j.theriogenology.2021.04.005. Epub 2021 Apr 18. [2]. Nobuhiro Hirakawa, et al. Anti-invasive activity of niacin and trigonelline against cancer cells. Biosci Biotechnol Biochem. 2005 Mar;69(3):653-8. [3]. Kang Cheng, et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6682-7. |
Chemical & Physical Properties
| Boiling Point | 292.5ºC at 760 mmHg |
|---|---|
| Melting Point | 236.6ºC |
| Molecular Formula | C6H6ClNO2 |
| Molecular Weight | 159.57000 |
| Flash Point | 130.7ºC |
| Exact Mass | 159.00900 |
| PSA | 50.19000 |
| LogP | 1.58180 |
| InChIKey | IBTWUVRCFHJPKN-UHFFFAOYSA-N |
| SMILES | Cl.O=C(O)c1cccnc1 |
Synonyms
| chloro nicotinic acid |
| Nicotinic acid,hydrochloride |
| 3-carboxypyridinium chloride |
| pyridine-3-carboxylic chloride |
| Niacin hydrochloride |
| Niacin HCl |
| 3-Pyridinecarboxylic acid,hydrochloride |
| Pyridine-3-carboxylic acid hydrochloride |
