Introduction：Basic information about CAS 444606-18-2|SB-681323, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | SB-681323 |
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| CAS Number | 444606-18-2 | Molecular Weight | 456.41700 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C23H19F3N4O3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 8-(2,6-difluorophenyl)-2-(1,3-dihydroxypropan-2-ylamino)-4-(4-fluoro-2-methylphenyl)pyrido[2,3-d]pyrimidin-7-one |
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| Synonym | More Synonyms |
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SB-681323 BiologicalActivity
| Description | Dilmapimod (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease. |
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| Related Catalog | Signaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Inflammation/Immunology |
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| In Vitro | Dilmapimod (SB-681323) potently inhibits p38 MAPK signaling, measured by inhibition of sorbitol-induced pHSP27 expression[1]. |
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| References | [1]. Singh D, et al. A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. J Clin Pharmacol. 2010 Jan;50(1):94-100. |
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Chemical & Physical Properties
| Molecular Formula | C23H19F3N4O3 |
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| Molecular Weight | 456.41700 |
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| Exact Mass | 456.14100 |
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| PSA | 103.50000 |
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| LogP | 2.36040 |
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| InChIKey | ORVNHOYNEHYKJG-UHFFFAOYSA-N |
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| SMILES | Cc1cc(F)ccc1-c1nc(NC(CO)CO)nc2c1ccc(=O)n2-c1c(F)cccc1F |
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Synonyms
| Dilmapimod |
| UNII-Q3238VQW0N |
| SB-681323 |
