CAS 618385-01-6|Vorapaxar

Introduction：Basic information about CAS 618385-01-6|Vorapaxar, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Vorapaxar BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Vorapaxar
CAS Number	618385-01-6	Molecular Weight	492.582
Density	1.3±0.1 g/cm3	Boiling Point	676.0±55.0 °C at 760 mmHg
Molecular Formula	C₂₉H₃₃FN₂O₄	Melting Point	/
MSDS	/	Flash Point	362.6±31.5 °C

Names

Name	vorapaxar
Synonym	More Synonyms

Vorapaxar BiologicalActivity

Description	Vorapaxar is a protease-activated receptor (PAR-1) antagonist that inhibits thrombin-induced platelet activation.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Protease-Activated Receptor (PAR)Research Areas >>Cardiovascular Disease
References	[1]. Khoufache K, et al. PAR1 contributes to influenza A virus pathogenicity in mice. J Clin Invest. 2013 Jan;123(1):206-14. [2]. Kehinde O, et al. Vorapaxar: A novel agent to be considered in the secondary prevention of myocardial infarction. J Pharm Bioallied Sci. 2016 Apr-Jun;8(2):98-105.

Description

Vorapaxar is a protease-activated receptor (PAR-1) antagonist that inhibits thrombin-induced platelet activation.

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Protease-Activated Receptor (PAR)Research Areas >>Cardiovascular Disease

References

[1]. Khoufache K, et al. PAR1 contributes to influenza A virus pathogenicity in mice. J Clin Invest. 2013 Jan;123(1):206-14.

[2]. Kehinde O, et al. Vorapaxar: A novel agent to be considered in the secondary prevention of myocardial infarction. J Pharm Bioallied Sci. 2016 Apr-Jun;8(2):98-105.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	676.0±55.0 °C at 760 mmHg
Molecular Formula	C₂₉H₃₃FN₂O₄
Molecular Weight	492.582
Flash Point	362.6±31.5 °C
Exact Mass	492.242432
PSA	81.01000
LogP	4.54
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.594
InChIKey	ZBGXUVOIWDMMJE-QHNZEKIYSA-N
SMILES	CCOC(=O)NC1CCC2C(C1)CC1C(=O)OC(C)C1C2C=Cc1ccc(-c2cccc(F)c2)cn1
Storage condition	-20℃

Synonyms

Carbamic acid, [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2- pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester

Ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]vinyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate

Carbamic acid, N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester

Vorapaxar

UNII-ZCE93644N2

ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate

Ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)-2- pyridinyl]vinyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-y l]carbamate

Ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]vinyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate

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