Introduction：Basic information about CAS 1346242-31-6|Rivastigmine carbamate impurity, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Rivastigmine carbamate impurity |
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| CAS Number | 1346242-31-6 | Molecular Weight | 224.21300 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C10H12N2O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | (3-nitrophenyl) N-ethyl-N-methylcarbamate |
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| Synonym | More Synonyms |
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Rivastigmine carbamate impurity BiologicalActivity
| Description | Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is an impurity of Rivastigmine. Rivastigmine is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively[1][2]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>AChE |
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| References | [1]. Ziwei Chen, et al. Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease. Eur J Med Chem. 2017 Jan 5;125:784-792. [2]. Qian-Sheng Yu, et al. Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines. J Med Chem. 2002 Aug 15;45(17):3684-91. |
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Chemical & Physical Properties
| Molecular Formula | C10H12N2O4 |
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| Molecular Weight | 224.21300 |
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| Exact Mass | 224.08000 |
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| PSA | 75.36000 |
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| LogP | 2.56850 |
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| InChIKey | DFECCKHSYUWCIJ-UHFFFAOYSA-N |
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| SMILES | CCN(C)C(=O)Oc1cccc([N+](=O)[O-])c1 |
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Safety Information
Synonyms
| 3-Nitrophenyl ethyl(methyl)carbamate |
| Rivastigmine tartrate impurity,carbamate impurity-[USP] |
| Carbamic acid,N-ethyl-N-methyl-,3-nitrophenyl ester |
| UNII-5EM63X2EYP |
