Introduction：Basic information about CAS 4443-09-8|Norwogonin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Norwogonin |
|---|
| CAS Number | 4443-09-8 | Molecular Weight | 270.23700 |
|---|
| Density | 1.548g/cm3 | Boiling Point | 528.4ºC at 760 mmHg |
|---|
| Molecular Formula | C15H10O5 | Melting Point | 258 ºC (ethanol ) |
|---|
| MSDS | / | Flash Point | 206ºC |
|---|
Names
| Name | norwogonin |
|---|
| Synonym | More Synonyms |
|---|
Norwogonin BiologicalActivity
| Description | Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (EV71) with an IC50 of 31.83 μg/ml[1] |
|---|
| Related Catalog | Research Areas >>Infection |
|---|
| Target | IC50: 31.83 μg/ml (EV71)[1] |
|---|
| In Vitro | Norwogonin (0.4, 2, 10, and 50 μg/mL; 48 hours) inhibits EV71 replication in Vero cells and prevents the cytotoxicity induced by EV71 infection[1]. Norwogonin (50 μg/mL; 48 hours) dramatically decreases viral VP2 protein expression[1]. Norwogonin (50 μg/mL; 48 hours) strongly decreases the expression of EV71 NCR gene at 48 h[1]. |
|---|
| References | [1]. Choi HJ, et al. Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71. Biomol Ther (Seoul). 2016 Sep 1;24(5):552-8. |
|---|
Chemical & Physical Properties
| Density | 1.548g/cm3 |
|---|
| Boiling Point | 528.4ºC at 760 mmHg |
|---|
| Melting Point | 258 ºC (ethanol ) |
|---|
| Molecular Formula | C15H10O5 |
|---|
| Molecular Weight | 270.23700 |
|---|
| Flash Point | 206ºC |
|---|
| Exact Mass | 270.05300 |
|---|
| PSA | 90.90000 |
|---|
| LogP | 2.57680 |
|---|
| Index of Refraction | 1.732 |
|---|
| InChIKey | ZFKKRRMUPBBYRS-UHFFFAOYSA-N |
|---|
| SMILES | O=c1cc(-c2ccccc2)oc2c(O)c(O)cc(O)c12 |
|---|
| Storage condition | 2-8°C |
|---|
| Water Solubility | Very slightly soluble (0.26 g/L) (25 ºC) |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- LK9276100
- CHEMICAL NAME :
- Flavone, 5,7,8-trihydroxy-
- CAS REGISTRY NUMBER :
- 4443-09-8
- BEILSTEIN REFERENCE NO. :
- 0272168
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C15-H10-O5
- MOLECULAR WEIGHT :
- 270.25
- WISWESSER LINE NOTATION :
- T66 BO EVJ CR& GQ IQ JQ
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 1 nmol/plate
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,474,1983
|
Safety Information
Customs
| HS Code | 2914400090 |
|---|
| Summary | 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
|---|
Synonyms
| Norwogonin |
| 5,7,8-Trihydroxyflavone |
| 5,7,8-trihydroxy-2-phenyl-chromen-4-one |
| FLAVONE,5,7,8-TRIHYDROXY |
| 2-Phenyl-5,7,8-trihydroxy-4H-1-benzopyran-4-one |
| 5,7,8-trihydroxy-2-phenylchromen-4-one |
| 5,7,8-Trihydroxy-2-phenyl-chromen-4-on |
