Introduction：Basic information about CAS 133-16-4|2-Diethylaminoethyl 4-amino-2-chloro-benzoate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-Diethylaminoethyl 4-amino-2-chloro-benzoate |
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| CAS Number | 133-16-4 | Molecular Weight | 307.21600 |
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| Density | 1.17g/cm3 | Boiling Point | 402.6ºC at 760mmHg |
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| Molecular Formula | C13H20Cl2N2O2 | Melting Point | / |
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| MSDS | / | Flash Point | 197.3ºC |
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Names
| Name | chloroprocaine |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Chloroprocaine (2-Chloroprocaine) is a potent inhibitor of Na,K-ATPase activity with an IC50 of 13 mM. Chloroprocaine blocks peripheral nerve[1]. |
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| Target | IC50: 13 mM (Na,K-ATPase)[1] |
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| In Vivo | In mice, the intravenous LD50 of Chloroprocaine HCl is 97 mg/kg and the subcutaneous LD50 of Chloroprocaine HCl is 950 mg/kg[2]. |
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| References | [1]. H Kutchai, et al. Inhibition of the Na,K-ATPase of Canine Renal Medulla by Several Local Anesthetics. Pharmacol Res. 2001 Apr;43(4):399-403. [2]. Chloroprocaine HCl Injection. |
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Chemical & Physical Properties
| Density | 1.17g/cm3 |
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| Boiling Point | 402.6ºC at 760mmHg |
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| Molecular Formula | C13H20Cl2N2O2 |
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| Molecular Weight | 307.21600 |
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| Flash Point | 197.3ºC |
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| Exact Mass | 306.09000 |
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| PSA | 55.56000 |
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| LogP | 3.80400 |
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| Vapour Pressure | 1.08E-06mmHg at 25°C |
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| Index of Refraction | 1.553 |
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| InChIKey | VDANGULDQQJODZ-UHFFFAOYSA-N |
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| SMILES | CCN(CC)CCOC(=O)c1ccc(N)cc1Cl |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DG1575100
- CHEMICAL NAME :
- Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester
- CAS REGISTRY NUMBER :
- 133-16-4
- BEILSTEIN REFERENCE NO. :
- 2808071
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C13-H19-Cl-N2-O2
- MOLECULAR WEIGHT :
- 270.79
- WISWESSER LINE NOTATION :
- ZR CG DVO2N2&2
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 64 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 3,525,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9329 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 48 (estimated) No. of Female Employees: 48 (estimated)
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Safety Information
Customs
| HS Code | 2922499990 |
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| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| 2-(diethylamino)ethyl 4-amino-2-chlorobenzoate |
| Chloroprocainum |
| Piocaine |
| Chloroprocain |
| Nesacaine |
| Chlorprocain |
| 2-Chloroprocaine |
| Halestyn |
| Chlorprocainum |
| Chlorprocaine |
| CHLOROPROCAINE |
