CAS 18524-94-2|Loganin
| Common Name | Loganin | ||
|---|---|---|---|
| CAS Number | 18524-94-2 | Molecular Weight | 390.382 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 608.8±55.0 °C at 760 mmHg |
| Molecular Formula | C17H26O10 | Melting Point | 222°C |
| MSDS | ChineseUSA | Flash Point | 217.9±25.0 °C |
Names
| Name | loganin |
|---|---|
| Synonym | More Synonyms |
Loganin BiologicalActivity
| Description | Loganin, a major iridoid glycoside obtained from Corni fructus, has been shown to have anti-inflammatory and anti-shock effects. Loganin exhibits an anti-inflammatory effect in cases of AP and its pulmonary complications through inhibition of NF-κB activation. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>OthersNatural Products >>Terpenoids and Glycosides |
| References | [1]. Kim MJ, et al. Loganin protects against pancreatitis by inhibiting NF-κB activation. Eur J Pharmacol. 2015 Oct 15;765:541-50. [2]. Tsai WH, et al. Ba-Wei-Di-Huang-Wan through its active ingredient loganin counteracts substance P-enhanced NF-κB/ICAM-1 signaling in rats with bladder hyperactivity. Neurourol Urodyn. 2015 Aug 19. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 608.8±55.0 °C at 760 mmHg |
| Melting Point | 222°C |
| Molecular Formula | C17H26O10 |
| Molecular Weight | 390.382 |
| Flash Point | 217.9±25.0 °C |
| Exact Mass | 390.152588 |
| PSA | 155.14000 |
| LogP | -2.73 |
| Vapour Pressure | 0.0±4.0 mmHg at 25°C |
| Index of Refraction | 1.600 |
| InChIKey | AMBQHHVBBHTQBF-UOUCRYGSSA-N |
| SMILES | COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C2C1CC(O)C2C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R22 |
| Safety Phrases | S22-S45 |
| RIDADR | 1544 |
| WGK Germany | 3 |
Articles34
More Articles| Allergy-preventive effects of chlorogenic acid and iridoid derivatives from flower buds of Lonicera japonica. Biol. Pharm. Bull. 34(8) , 1330-3, (2011) Allergy-preventive activity of flower buds of Lonicera japonica THUNB. was found in the 35% EtOH extract (LJ) using an in vivo assay, The assay system uses monitoring of a decrease in blood flow (BF) ... | |
| [Optimization of microwave-assisted extraction with RSM and HPLC determination for three iridoid glycosides in Cornus officinalis]. Zhong Yao Cai 34(7) , 1118-22, (2011) To establish a method of microwave-assisted extraction and high performance liquid chromatographic (HPLC) for simultaneous determination of three iridoid glycosides including loganin, sweroside and co... | |
| Anti-inflammatory and analgesic activities of SKLJI, a highly purified and injectable herbal extract of Lonicera japonica. Biosci. Biotechnol. Biochem. 74(10) , 2022-8, (2010) The parenteral route has many merits over the oral route, including greater predictability, reproducibility of absorption, and rapid drug action, but injectable phytomedicines are uncommon due to prot... |
Synonyms
| 7-HYDROXY-6-DESOXYVERBENALIN |
| (1S,4aS,6S,7R,7aS)-1-(β-D-Glucopyranosyloxy)-6-hydroxy-7-méthyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate de méthyle |
| Loganoside |
| Cuchiloside |
| Cyclopenta[c]pyran-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methyl-, methyl ester, (1S,4aS,6S,7R,7aS)- |
| Methyl (1S,4aS,6S,7R,7aS)-1-(β-D-glucopyranosyloxy)-6-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate |
| LOGANINE |
| Loganin |
| MFCD00075645 |
| (1S,4aS,6S,7R,7aS)-6-Hydroxy-7-méthyl-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate de méthyle |
| loganic acid methyl ester |
| Methyl (1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate |
| 1-(b-D-Glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic Acid Methyl Ester |
| Methyl-(1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylat |
| Loganin, loganoside |
| Meliatin |
| EINECS 242-398-0 |
