CAS 4429-63-4|Tabersonine

Introduction：Basic information about CAS 4429-63-4|Tabersonine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Tabersonine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles1
7. Synonyms

Common Name	Tabersonine
CAS Number	4429-63-4	Molecular Weight	336.427
Density	1.3±0.1 g/cm3	Boiling Point	488.7±45.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₄N₂O₂	Melting Point	/
MSDS	ChineseUSA	Flash Point	249.4±28.7 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	tabersonine
Synonym	More Synonyms

Tabersonine BiologicalActivity

Description	Tabersonine is an indole alkaloid mainly isolated from Catharanthus roseus. Tabersonine disrupts Aβ(1-42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. Tabersonine has anti-inflammatory activities and acts as a potential therapeutic candidate for the treatment of ALI/ARDS[1].
Related Catalog	Signaling Pathways >>Others >>Others
References	[1]. Zhang D, et al. Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination. Biochem Pharmacol. 2018 Aug;154:183-192.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	488.7±45.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₄N₂O₂
Molecular Weight	336.427
Flash Point	249.4±28.7 °C
Exact Mass	336.183777
PSA	41.57000
LogP	3.57
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.652
InChIKey	FNGGIPWAZSFKCN-ACRUOGEOSA-N
SMILES	CCC12C=CCN3CCC4(C(=C(C(=O)OC)C1)Nc1ccccc14)C32
Storage condition	2-8C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CJ0150000

CHEMICAL NAME :: Aspidospermidine-3-carboxylic acid, 2,3,6,7-tetrahydro-, methyl ester, (5-alpha,12-beta, 19-alpha)-

CAS REGISTRY NUMBER :: 4429-63-4

BEILSTEIN REFERENCE NO. :: 0050163

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H24-N2-O2

MOLECULAR WEIGHT :: 336.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 13,123,1955

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport

Articles1

Analysis of Indole Alkaloids from Rhazya stricta Hairy Roots by Ultra-Performance Liquid Chromatography-Mass Spectrometry.

Molecules 20 , 22621-34, (2015)

Rhazya stricta Decne. (Apocynaceae) contains a large number of terpenoid indole alkaloids (TIAs). This study focused on the composition of alkaloids obtained from transformed hairy root cultures of R....

Synonyms

EINECS 224-615-0

(-)-Tabersonine

TABERSONINE

Methyl (5α,19α)-2,3,6,7-tetradehydroaspidospermidine-3-carboxylate

methyl 2,3,6,7-tetradehydro-5α,12β,19α-aspidospermidine-3-carboxylate

Aspidospermidine-3-carboxylic acid, 2,3,6,7-tetradehydro-, methyl ester, (5α,19α)-

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