Introduction：Basic information about CAS 5890-18-6|Laurolitsine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Laurolitsine |
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| CAS Number | 5890-18-6 | Molecular Weight | 313.348 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 553.0±50.0 °C at 760 mmHg |
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| Molecular Formula | C18H19NO4 | Melting Point | 138-140ºC |
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| MSDS | / | Flash Point | 288.3±30.1 °C |
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Names
| Name | laurolistine |
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| Synonym | More Synonyms |
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Laurolitsine BiologicalActivity
| Description | Laurolitsine ((+)-Norboldine) is an alkaloid isolated from the leaves of Peumus boldus Molina[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| References | [1]. Teng CM, et al. Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. J Pharm Pharmacol. 1997 Jul;49(7):706-11. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 553.0±50.0 °C at 760 mmHg |
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| Melting Point | 138-140ºC |
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| Molecular Formula | C18H19NO4 |
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| Molecular Weight | 313.348 |
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| Flash Point | 288.3±30.1 °C |
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| Exact Mass | 313.131409 |
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| PSA | 70.95000 |
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| LogP | 1.43 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.643 |
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| InChIKey | KYVJVURXKAZJRK-LBPRGKRZSA-N |
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| SMILES | COc1cc2c(cc1O)CC1NCCc3cc(O)c(OC)c-2c31 |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- RB5935000
- CHEMICAL NAME :
- 6a-alpha-Noraporphine-2,9-diol, 1,10-dimethoxy-
- CAS REGISTRY NUMBER :
- 5890-18-6
- LAST UPDATED :
- 198208
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C18-H19-N-O4
- MOLECULAR WEIGHT :
- 313.38
- WISWESSER LINE NOTATION :
- T C6666 1A Q KM&TT&J EO1 FQ PQ QO1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 450 mg/kg
- TOXIC EFFECTS :
- Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 170 mg/kg
- TOXIC EFFECTS :
- Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980
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Synonyms
| Norisoboidine |
| (6aS)-1,10-Dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol |
| Norboldine |
| laurolistine |
| LAUROLITSINE |
| 4H-Dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-, (6aS)- |
