CAS 4481-62-3|Betulonic acid

Introduction：Basic information about CAS 4481-62-3|Betulonic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Betulonic acid BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Betulonic acid
CAS Number	4481-62-3	Molecular Weight	454.684
Density	1.1±0.1 g/cm3	Boiling Point	548.1±33.0 °C at 760 mmHg
Molecular Formula	C₃₀H₄₆O₃	Melting Point	264 °C
MSDS	/	Flash Point	299.4±21.9 °C

Names

Name	Betulonicacid
Synonym	More Synonyms

Betulonic acid BiologicalActivity

Description	Betulonic acid belongs to the pentacyclic triterpenic derivative class, has antitumor activities.In vitro: BEA-NP is found over three-times more permeable than that solubilized by DMSO in Caco-2 cell monocultures.[1]In vivo: The tumor growth in the S180 berry mice orally doses with BEA-NP at 75 mg/kg is inhibited by 50%. Rubusoside is effective in solubilizing BEA, maintaining its cytotoxicity, enhancing its permeability and reducing tumor growth when orally administered.[1] antitumor activities against MGC-803, PC3, Bcap-37, A375, and MCF-7 human cancer cell lines In vivo: The animals are treated with betulonic acid amide (50 mg/kg in Tween aqueous solution) and heptral (6 mg/kg) as hepatoprotective compounds. It is found that betulonic acid amide stimulats the regenerative response in hepatocytes under conditions of combined toxic exposure and promots recovery of their qualitative and quantitative characteristics. [2]
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>OthersNatural Products >>Terpenoids and Glycosides
References	[1]. Zhang J et al. Employing rubusoside to improve the solubility and permeability of antitumor compound betulonic acid. Nanomedicine (Lond). 2016 Oct 19. [2]. Semenov DE et al. Hepatoprotective properties of betulonic acid amide and heptral in toxic liver injury induced by carbon tetrachloride in combination with ethanol.Bull Exp Biol Med. 2015 Jan;158(3):336-41.

Description

Betulonic acid belongs to the pentacyclic triterpenic derivative class, has antitumor activities.In vitro: BEA-NP is found over three-times more permeable than that solubilized by DMSO in Caco-2 cell monocultures.[1]In vivo: The tumor growth in the S180 berry mice orally doses with BEA-NP at 75 mg/kg is inhibited by 50%. Rubusoside is effective in solubilizing BEA, maintaining its cytotoxicity, enhancing its permeability and reducing tumor growth when orally administered.[1] antitumor activities against MGC-803, PC3, Bcap-37, A375, and MCF-7 human cancer cell lines In vivo: The animals are treated with betulonic acid amide (50 mg/kg in Tween aqueous solution) and heptral (6 mg/kg) as hepatoprotective compounds. It is found that betulonic acid amide stimulats the regenerative response in hepatocytes under conditions of combined toxic exposure and promots recovery of their qualitative and quantitative characteristics. [2]

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>OthersNatural Products >>Terpenoids and Glycosides

References

[1]. Zhang J et al. Employing rubusoside to improve the solubility and permeability of antitumor compound betulonic acid. Nanomedicine (Lond). 2016 Oct 19.

[2]. Semenov DE et al. Hepatoprotective properties of betulonic acid amide and heptral in toxic liver injury induced by carbon tetrachloride in combination with ethanol.Bull Exp Biol Med. 2015 Jan;158(3):336-41.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	548.1±33.0 °C at 760 mmHg
Melting Point	264 °C
Molecular Formula	C₃₀H₄₆O₃
Molecular Weight	454.684
Flash Point	299.4±21.9 °C
Exact Mass	454.344696
PSA	54.37000
LogP	8.36
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.527
InChIKey	SLJTWDNVZKIDAU-SVAFSPIFSA-N
SMILES	C=C(C)C1CCC2(C(=O)O)CCC3(C)C(CCC4C5(C)CCC(=O)C(C)(C)C5CCC43C)C12

Safety Information

Hazard Codes	Xi
Safety Phrases	24/25

Synonyms

Betulinonic acid

3-Oxolup-20(29)-en-28-oic acid

Liquidambaricacid

Betulonic acid

Lup-20(29)-en-28-oic acid, 3-oxo-

LiquidaMba

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