Introduction：Basic information about CAS 25086-89-9|Poly(1-vinylpyrrolidone-co-vinyl acetate), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Poly(1-vinylpyrrolidone-co-vinyl acetate) |
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| CAS Number | 25086-89-9 | Molecular Weight | 486.726 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 536.7±50.0 °C at 760 mmHg |
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| Molecular Formula | (C6H9NO.C4H6O2)n | Melting Point | / |
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| MSDS | USA | Flash Point | 254.7±28.5 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | Poly(1-vinylpyrrolidone-co-vinyl acetate) |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Copovidone can be used as an excipient, such as Film formers, adhesives, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| References | [1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99. |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
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| Boiling Point | 536.7±50.0 °C at 760 mmHg |
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| Molecular Formula | (C6H9NO.C4H6O2)n |
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| Molecular Weight | 486.726 |
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| Flash Point | 254.7±28.5 °C |
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| Exact Mass | 486.370911 |
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| PSA | 46.61000 |
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| LogP | 9.76 |
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| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
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| Index of Refraction | 1.517 |
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| InChIKey | FYUWIEKAVLOHSE-UHFFFAOYSA-N |
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| SMILES | C=CN1CCCC1=O.C=COC(C)=O |
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| Stability | Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents. |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- AH3539000
- CHEMICAL NAME :
- Acetic acid, ethenyl ester, polymer with 1-ethenyl-2-pyrrolidinone
- CAS REGISTRY NUMBER :
- 25086-89-9
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 4
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >630 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia
- REFERENCE :
- JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 2(5),141,1983
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H302 |
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| Precautionary Statements | P301 + P312 + P330 |
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi |
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| Risk Phrases | R10 |
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| Safety Phrases | S22-S24/25 |
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| RIDADR | UN 1987 3/PG 2 |
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| WGK Germany | 1 |
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| RTECS | AH3539000 |
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| Packaging Group | II |
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| Hazard Class | 3.0 |
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Synonyms
| copolyvidone |
| kolima35 |
| gaf-s630 |
| Cholest-8(14)-ene-3,6-diyl diacetate |
| kolima10 |
| s630 |
| Cholest-8(14)-ene-3,6-diol, diacetate |
| MFCD00134018 |
| pvp-va |
| VP/VA Copolymers Powder |
