CAS 446-35-5|2,4-Difluoronitrobenzene

Introduction：Basic information about CAS 446-35-5|2,4-Difluoronitrobenzene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
4. Safety Information
5. Customs
6. Articles4
7. Synonyms

Common Name	2,4-Difluoronitrobenzene
CAS Number	446-35-5	Molecular Weight	159.090
Density	1.5±0.1 g/cm3	Boiling Point	207.0±0.0 °C at 760 mmHg
Molecular Formula	C₆H₃F₂NO₂	Melting Point	9-10 °C(lit.)
MSDS	ChineseUSA	Flash Point	90.6±0.0 °C
Symbol	GHS06	Signal Word	Danger

Names

Name	2,4-Difluoronitrobenzene
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	207.0±0.0 °C at 760 mmHg
Melting Point	9-10 °C(lit.)
Molecular Formula	C₆H₃F₂NO₂
Molecular Weight	159.090
Flash Point	90.6±0.0 °C
Exact Mass	159.013184
PSA	45.82000
LogP	1.58
Vapour density	>1 (vs air)
Vapour Pressure	0.3±0.3 mmHg at 25°C
Index of Refraction	1.510
InChIKey	RJXOVESYJFXCGI-UHFFFAOYSA-N
SMILES	O=[N+]([O-])c1ccc(F)cc1F
Stability	Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ5730000

CHEMICAL NAME :: Benzene, 2,4-difluoro-1-nitro-

CAS REGISTRY NUMBER :: 446-35-5

BEILSTEIN REFERENCE NO. :: 2048034

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H3-F2-N-O2

MOLECULAR WEIGHT :: 159.10

WISWESSER LINE NOTATION :: WNR BF DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - chromodacryorrhea Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1290 mg/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 80 nL/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 116,217,1983

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H315-H319-H335
Precautionary Statements	P261-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T:Toxic
Risk Phrases	R23/24/25;R36/37/38
Safety Phrases	S26-S45-S36/37/39-S23
RIDADR	UN 2810 6.1/PG 1
WGK Germany	3
RTECS	CZ5730000
Packaging Group	III
Hazard Class	6.1
HS Code	2904909090

Customs

HS Code	2904909090
Summary	HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles4

A direct synthesis of 2-arylpropenoic acid esters having nitro groups in the aromatic ring: a short synthesis of (±)-coerulescine and (±)-horsfiline. Selvakumar N, et al.

Tetrahedron Lett. 43(50) , 9175-78, (2002)

A solid phase traceless synthesis of 2-arylaminobenzimidazoles. Krchnák V, et al.

Tetrahedron Lett. 42(9) , 1627-30, (2001)

Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography.

Angew. Chem. Int. Ed. Engl. 51(28) , 7028-30, (2012)

Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desi...

Synonyms

2,4-difluoro-1-nitro-benzene

2.4 DFNB

2,4-difluoro-1-nitro-benzen

2,4-DIFLUORO NITROBENZEN

MFCD00007050

1,3-difluoro-4-nitrobenzene

2,4-Difluronitrobenzene

3,5-diflurobenzonitrile

2,4-Difluoronitroben

1-nitro-2,4-difluorobenzene

Benzene, 2,4-difluoro-1-nitro-

2,4-Difluoro-1-nitrobenzene

EINECS 207-167-0

2,4-Difluoronitribenzene

2,4-Difluoronitrobenzene

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