CAS 4434-05-3|COUMERMYCIN AL

Introduction：Basic information about CAS 4434-05-3|COUMERMYCIN AL, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. COUMERMYCIN AL BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Articles26
7. Synonyms

Common Name	COUMERMYCIN AL
CAS Number	4434-05-3	Molecular Weight	1110.08000
Density	/	Boiling Point	/
Molecular Formula	C₅₅H₅₉N₅O₂₀	Melting Point	/
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS07	Signal Word	Warning

Names

Name	coumermycin A1
Synonym	More Synonyms

COUMERMYCIN AL BiologicalActivity

Description	Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria.
Related Catalog	Research Areas >>Metabolic DiseaseSignaling Pathways >>Anti-infection >>Bacterial
In Vitro	Coumermycin A1-induced-JAK2 signal activation increases the mRNA level of SCOS2, but reducea leptin receptor mRNA level[1].
References	[1]. Tiantian Zhang, et al. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes. Research Article.

Chemical & Physical Properties

Molecular Formula	C₅₅H₅₉N₅O₂₀
Molecular Weight	1110.08000
Exact Mass	1109.38000
PSA	354.89000
LogP	5.71790
InChIKey	WTIJXIZOODAMJT-DHFGXMAYSA-N
SMILES	COC1C(OC(=O)c2ccc(C)[nH]2)C(O)C(Oc2ccc3c(O)c(NC(=O)c4c[nH]c(C(=O)Nc5c(O)c6ccc(OC7OC(C)(C)C(OC)C(OC(=O)c8ccc(C)[nH]8)C7O)c(C)c6oc5=O)c4C)c(=O)oc3c2C)OC1(C)C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9375000

CHEMICAL NAME :: Pyrrole-2-carboxylic acid, 5-methyl-, diester with 3,3'-((3-methylpyrrole-2,4-diyl) bis(carbonylimino))bis(7-((5,5-di-C-methyl-4-O-methyl -alpha-L-lyxopyranosy l)oxy)-4-hydroxy -8-methylcoumarin)

CAS REGISTRY NUMBER :: 4434-05-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C55-H59-N5-O20

MOLECULAR WEIGHT :: 1110.19

WISWESSER LINE NOTATION :: T66 BOVJ EQ J1 IO- FT6OTJ B1 B1 CO1 EQ DOV- BT5MJ E1&& DMV- DT5M BUTJ C1 BVM- DT66 BOVJ EQ J1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 159 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 200 mg/L

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 271,385,1978

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	22
Safety Phrases	36
RIDADR	NONH for all modes of transport
RTECS	UX9375000

Articles26

Multiplexing interactions to control antibiotic release from cyclodextrin hydrogels.

Macromol. Biosci. 11(11) , 1544-52, (2011)

A new strategy for affinity-based drug delivery by modification of the drug rather than modification of the device is presented. Rifampin is modified to contain either one or two PEG-adamantane arms, ...

Aminocoumarins inhibit osteoclast differentiation and bone resorption via downregulation of nuclear factor of activated T cells c1.

Biochem. Pharmacol. 85(3) , 417-25, (2013)

Aminocoumarins, such as coumermycin A1 and novobiocin, are natural products of streptomycetes. They are potent inhibitors of bacterial DNA gyrase and are used to suppress the growth of bacteria in inf...

Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization.

J. Biol. Chem. 281 , 7161-7171, (2006)

The C-terminal domain of Hsp90 displays independent chaperone activity, mediates dimerization, and contains the MEEVD motif essential for interaction with tetratricopeptide repeat-containing immunophi...

Synonyms

coumamycin

l)oxy)-4-hydroxy-8-methylcoumarin)

Sugordomycin D-la

Coumermycin

Cumamycin

coumermycins

notomycina1

COUMERMYCIN A1

Notomycin

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