Introduction：Basic information about CAS 132465-11-3|Cinnamyl-3,4-dihydroxy-α-cyanocinnamate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cinnamyl-3,4-dihydroxy-α-cyanocinnamate |
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| CAS Number | 132465-11-3 | Molecular Weight | 321.32700 |
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| Density | 1.326 g/cm3 | Boiling Point | 583.9ºC at 760 mmHg |
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| Molecular Formula | C19H15NO4 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 307ºC |
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| Symbol |
GHS07, GHS09 | Signal Word | Warning |
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Names
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate BiologicalActivity
| Description | Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent 12/15-Lipoxygenases (LO) inhibitor. Cinnamyl-3,4-dihydroxy-α-cyanocinnamate has the potential for the research of type 1 diabetes mellitus[1]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>5-LipoxygenaseResearch Areas >>Metabolic Disease |
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| In Vitro | High glucose or 12(S)-HETE remarkably increased transendothelial dextran transport, and in combination it was increased further. Addition of the 12/15-LO inhibitor, CDC, partially suppressed dextran transport[1]. |
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| In Vivo | The high glucose and 12(S)-hydroxyeicosatetraenoic acid (HETE) could alter vascular endothelial (VE)-cadherin and β‐catenin phosphorylation levels, but did not alter total protein expression. However, the 12/15-LO inhibitor, Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), antagonized the effect of high glucose on protein phosphorylation to mitigate destruction of the endothelial cell barrier, and the mouse diabetes mellitus model further confirmed these conclusions[1]. |
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| References | [1]. Wang X, et al. 12(S)-hydroxyeicosatetraenoic acid impairs vascular endothelial permeability by altering adherens junction phosphorylation levels and affecting the binding and dissociation of its components in high glucose-induced vascular injury. J Diabetes Investig. 2019;10(3):639-649. |
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Chemical & Physical Properties
| Density | 1.326 g/cm3 |
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| Boiling Point | 583.9ºC at 760 mmHg |
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| Molecular Formula | C19H15NO4 |
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| Molecular Weight | 321.32700 |
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| Flash Point | 307ºC |
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| Exact Mass | 321.10000 |
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| PSA | 90.55000 |
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| LogP | 3.26138 |
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| InChIKey | XGHYFEJMJXGPGN-UYHGDYIZSA-N |
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| SMILES | N#CC(=Cc1ccc(O)c(O)c1)C(=O)OCC=Cc1ccccc1 |
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| Storage condition | -20°C |
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Safety Information
| Symbol |
GHS07, GHS09 |
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| Signal Word | Warning |
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| Hazard Statements | H317-H410 |
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| Precautionary Statements | P273-P280-P501 |
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| Hazard Codes | Xi |
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| Risk Phrases | 43-50/53 |
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| Safety Phrases | 36/37-60-61 |
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| RIDADR | UN 3077 9 / PGIII |
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