CAS 1672-46-4|Digoxigenin

Introduction：Basic information about CAS 1672-46-4|Digoxigenin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Digoxigenin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles303
7. Synonyms

Common Name	Digoxigenin
CAS Number	1672-46-4	Molecular Weight	390.51300
Density	1.297 g/cm3	Boiling Point	589.4ºC at 760 mmHg
Molecular Formula	C₂₃H₃₄O₅	Melting Point	222 °C(lit.)
MSDS	ChineseUSA	Flash Point	203ºC
Symbol	GHS06	Signal Word	Danger

Names

Name	digoxigenin
Synonym	More Synonyms

Digoxigenin BiologicalActivity

Description	Digoxigenin is a hapten, a small molecule with high antigenicity, that is used in many molecular biology applications, as an alternative probe labeling for in situ hybridization
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology

Chemical & Physical Properties

Density	1.297 g/cm3
Boiling Point	589.4ºC at 760 mmHg
Melting Point	222 °C(lit.)
Molecular Formula	C₂₃H₃₄O₅
Molecular Weight	390.51300
Flash Point	203ºC
Exact Mass	390.24100
PSA	86.99000
LogP	2.57510
Vapour Pressure	2.4E-16mmHg at 25°C
Index of Refraction	1.609
InChIKey	SHIBSTMRCDJXLN-KCZCNTNESA-N
SMILES	CC12CCC(O)CC1CCC1C2CC(O)C2(C)C(C3=CC(=O)OC3)CCC12O
Storage condition	2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FH5390000

CHEMICAL NAME :: 5-beta-Card-20(22)-enolide, 3-beta,12-beta,14-trihydroxy-

CAS REGISTRY NUMBER :: 1672-46-4

BEILSTEIN REFERENCE NO. :: 0096479

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C23-H34-O5

MOLECULAR WEIGHT :: 390.57

WISWESSER LINE NOTATION :: L E5 B666TJ A1 DQ E1 F- DT5OV CUTJ IQ OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 244 ug/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

REFERENCE :: JPHAA3 Journal of the American Pharmaceutical Association. (Washington, DC) V.1-28, 1912-39; New series: V.1-17, 1961-77. Volume(issue)/page/year: 27,189,1938

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 285 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,55,1963

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3545 ug/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - convulsions or effect on seizure threshold Cardiac - other changes

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 153,436,1965

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 1620 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 8,18,1960 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,190,1963

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300-H310-H330
Precautionary Statements	P260-P264-P280-P284-P302 + P350-P310
Hazard Codes	T+: Very toxic;
Risk Phrases	R26/27/28
Safety Phrases	S36/37/39-S45
RIDADR	UN 2811 6.1/PG 1
WGK Germany	3
RTECS	FH5390000
Packaging Group	II
Hazard Class	6.1(a)

Articles303

Proper migration and axon outgrowth of zebrafish cranial motoneuron subpopulations require the cell adhesion molecule MDGA2A.

Biol. Open 4(2) , 146-54, (2015)

The formation of functional neuronal circuits relies on accurate migration and proper axonal outgrowth of neuronal precursors. On the route to their targets migrating cells and growing axons depend on...

Long-distance retinoid signaling in the zebra finch brain.

PLoS ONE 9(11) , e111722, (2014)

All-trans retinoic acid (ATRA), the main active metabolite of vitamin A, is a powerful signaling molecule that regulates large-scale morphogenetic processes during vertebrate embryonic development, bu...

Local synthesis of interferon-alpha in lupus nephritis is associated with type I interferons signature and LMP7 induction in renal tubular epithelial cells.

Arthritis. Res. Ther. 17 , 72, (2015)

Type I interferons are pivotal in the activation of autoimmune response in systemic lupus erythematous. However, the pathogenic role of interferon-alpha in patients affected by lupus nephritis remains...

Synonyms

Lanadigenin

digitoxigenin

MFCD00871861

Lanadigigenin

3-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3,12,14-trihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

Digoxigenine

Digoxigenin

EINECS 216-806-2

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