CAS 13368-13-3|ETHYLENE GLYCOL-BIS(BETA-AMINOETHYL ETHER)-N,N,N',N'-TETRAACETIC ACID
| Common Name | ETHYLENE GLYCOL-BIS(BETA-AMINOETHYL ETHER)-N,N,N',N'-TETRAACETIC ACID TETRASODIUM SALT | ||
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| CAS Number | 13368-13-3 | Molecular Weight | 468.275 |
| Density | / | Boiling Point | / |
| Molecular Formula | C14H20N2Na4O10 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Ethylene glycol-bis(beta-aminoethyl ether)-N,N,N,N-tetraacetic acid tetrasodium salt |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| In Vitro | EGTA tetrasodium, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA tetrasodium concentration that causes an IC50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules[2]. |
| References | [1]. Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267(5 Pt 1):C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426. [2]. Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29(3):211-213. |
Chemical & Physical Properties
| Molecular Formula | C14H20N2Na4O10 |
|---|---|
| Molecular Weight | 468.275 |
| Exact Mass | 468.070862 |
| PSA | 185.46000 |
| InChIKey | BAOGCDPNNOBWQZ-UHFFFAOYSA-J |
| SMILES | O=C([O-])CN(CCOCCOCCN(CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Na+].[Na+] |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
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Synonyms
| tetrasodium,2-[2-[2-[2-[bis(carboxylatomethyl)amino]ethoxy]ethoxy]ethyl-(carboxylatomethyl)amino]acetate |
| Tetrasodium 3,12-bis(carboxylatomethyl)-6,9-dioxa-3,12-diazatetradecane-1,14-dioate |
| Ethylene glycol-bis(beta-aminoethyl ether)-N,N,N′,N′-tetraacetic acid tetrasodium salt |
