Introduction：Basic information about CAS 1638-41-1|p38 MAP Kinase Inhibitor IV, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | p38 MAP Kinase Inhibitor IV |
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| CAS Number | 1638-41-1 | Molecular Weight | 456.94100 |
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| Density | 1.854 g/cm3 | Boiling Point | 590ºC at 760 mmHg |
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| Molecular Formula | C12H4Cl6O4S | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 310.6ºC |
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Names
| Name | phenol,2,2'-sulfonylbis[3,4,6-trichloro] |
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| Synonym | More Synonyms |
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p38 MAP Kinase Inhibitor IV BiologicalActivity
| Description | p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC50s of 0.13 and 0.55 μM for p38α and p38β MAPK, respectively[1]. |
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| Related Catalog | Signaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Inflammation/Immunology |
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| Target | p38α:0.13 μM (IC50) p38β:0.55 μM (IC50) p38δ:8.63 μM (IC50) p38χ:5.47 μM (IC50) |
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| In Vitro | p38 MAP Kinase Inhibitor IV (MT4) shows IC50 values of 0.13, 0.55, 5.47, and 8.63μM for p38α, β, χ, andδ, respectively. p38 MAP Kinase Inhibitor IV has the suppressive action on the release of TNF-alpha and IL-1beta in PBMC with IC50 values of 22 and 44 nM, respectively[1]. |
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| References | [1]. Liu YC, et al. Identification of a novel competitive inhibitor of p38alpha MAPK by a human PBMC screen. Biochem Biophys Res Commun. 2007;352(3):656-661. |
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Chemical & Physical Properties
| Density | 1.854 g/cm3 |
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| Boiling Point | 590ºC at 760 mmHg |
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| Molecular Formula | C12H4Cl6O4S |
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| Molecular Weight | 456.94100 |
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| Flash Point | 310.6ºC |
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| Exact Mass | 453.79600 |
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| PSA | 82.98000 |
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| LogP | 6.93180 |
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| InChIKey | AKUKHICVNCCQHN-UHFFFAOYSA-N |
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| SMILES | O=S(=O)(c1c(O)c(Cl)cc(Cl)c1Cl)c1c(O)c(Cl)cc(Cl)c1Cl |
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Safety Information
| RIDADR | NONH for all modes of transport |
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| HS Code | 2908999090 |
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Customs
| HS Code | 2908999090 |
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| Summary | 2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| p38 MAP Kinase Inhibitor IV |
| 2,2'-Sulfonylbis(3,4,6-trichlorophenol) |
| Bis-(3,5,6-Trichlor-2-hydroxyphenyl)-sulfon |
| Bis-(3,5,6-trichlor-2-hydroxyphenyl)sulfid |
