CAS 444-27-9|Timonacic

Introduction：Basic information about CAS 444-27-9|Timonacic, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Timonacic BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Timonacic
CAS Number	444-27-9	Molecular Weight	133.169
Density	1.4±0.1 g/cm3	Boiling Point	350.3±37.0 °C at 760 mmHg
Molecular Formula	C₄H₇NO₂S	Melting Point	199 - 201ºC
MSDS	/	Flash Point	165.7±26.5 °C

Names

Name	thioproline
Synonym	More Synonyms

Timonacic BiologicalActivity

Description	Timonacic is used as an adjuvant in the treatment of acute and hepatic disorders. It has also been used for the treatment of some cases of cancer, through the induction of the reverse transformation.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>CancerResearch Areas >>Cardiovascular Disease
References	[1]. Bakry RS, et al. Spectrophotometric investigation of the formed chelate between timonacic and palladium(II) and its analytical applications. J Pharm Biomed Anal. 1998 May;17(1):95-101.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	350.3±37.0 °C at 760 mmHg
Melting Point	199 - 201ºC
Molecular Formula	C₄H₇NO₂S
Molecular Weight	133.169
Flash Point	165.7±26.5 °C
Exact Mass	133.019745
PSA	74.63000
LogP	-0.39
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.566
InChIKey	DZLNHFMRPBPULJ-UHFFFAOYSA-N
SMILES	O=C(O)C1CSCN1
Storage condition	2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ5425000

CHEMICAL NAME :: 4-Thiazolidinecarboxylic acid

CAS REGISTRY NUMBER :: 444-27-9

LAST UPDATED :: 199709

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C4-H7-N-O2-S

MOLECULAR WEIGHT :: 133.18

WISWESSER LINE NOTATION :: T5M CSTJ EVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Kidney, Ureter, Bladder - renal function tests depressed

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,778,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 875 mg/kg

TOXIC EFFECTS :: Liver - other changes

REFERENCE :: DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,399,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 494 mg/kg

TOXIC EFFECTS :: Liver - other changes

REFERENCE :: DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,399,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GMITAB Gazzetta Medica Italiana. (Turin, Italy) V.95-142, 1936-83. Volume(issue)/page/year: 131,265,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,68,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 715 mg/kg/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 64,837,1980 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 30 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Endocrine - effect on menstrual cycle

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,453,1987

Safety Information

RIDADR	UN 2811
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2934999090

Customs

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

(4R)-1,3-Thiazolidine-4-carboxylic acid

L-4-Thiazolidinecarboxylic acid

L-Thioproline

(R)-(-)-4-Thiazolidinecarboxylic acid

L- thiazolidine-4-carboxylic acid

MFCD00128958

EINECS 207-146-6

(4R)-4-Thiazolidinecarboxylic acid

(R)-Thiazolidine-4-carboxylic acid

4-thiazolidinecarboxylic acid

1-thiazolidine-4-carboxylic acid

L-Thiazolidine-4-carboxylic acid

Thiazolidine-4-carboxylic acid

4-Thiazolidinecarboxylic acid, (4R)-

Timonacic

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