CAS 36700-45-5|8-Shogaol
Introduction：Basic information about CAS 36700-45-5|8-Shogaol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 8-Shogaol | ||
|---|---|---|---|
| CAS Number | 36700-45-5 | Molecular Weight | 304.424 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 452.3±35.0 °C at 760 mmHg |
| Molecular Formula | C19H28O3 | Melting Point | / |
| MSDS | / | Flash Point | 154.6±19.4 °C |
Names
| Name | (E)-1-(4-hydroxy-3-methoxyphenyl)dodec-4-en-3-one |
|---|---|
| Synonym | More Synonyms |
8-Shogaol BiologicalActivity
| Description | [8]-Shogaol, one of the pungent phenolic compounds in ginger, exhibits anti-platelet activity (IC50=5 μM) and inhibits COX-2 (IC50=17.5 μM). [8]-Shogaol induces apoptosis in human leukemia cells[1][2][3][4]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Immunology/Inflammation >>COX |
| Target | COX-2:17.5 μM (IC50) |
| References | [1]. Shieh PC, et al. Induction of apoptosis by [8]-shogaol via reactive oxygen species generation, glutathione depletion, and caspase activation in human leukemia cells. J Agric Food Chem. 2010 Mar 24;58(6):3847-54. [2]. van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia. 2011 Jan;82(1):38-43. [3]. Nurtjahja-Tjendraputra E, et al. Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. Thromb Res. 2003;111(4-5):259-65. [4]. Shieh PC, et al. Induction of apoptosis by [8]-shogaol via reactive oxygen species generation, glutathione depletion, and caspase activation in human leukemia cells. J Agric Food Chem. 2010 Mar 24;58(6):3847-54. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 452.3±35.0 °C at 760 mmHg |
| Molecular Formula | C19H28O3 |
| Molecular Weight | 304.424 |
| Flash Point | 154.6±19.4 °C |
| Exact Mass | 304.203857 |
| PSA | 46.53000 |
| LogP | 4.91 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.516 |
| InChIKey | LGZSMXJRMTYABD-MDZDMXLPSA-N |
| SMILES | CCCCCCCC=CC(=O)CCc1ccc(O)c(OC)c1 |
Synonyms
| 4-Dodecen-3-one, 1-(4-hydroxy-3-methoxyphenyl)-, (4E)- |
| (4E)-1-(4-hydroxy-3-methoxyphenyl)dodec-4-en-3-one |
| 8-Shogaol |
| (4E)-1-(4-Hydroxy-3-methoxyphenyl)-4-dodecen-3-one |
