CAS 366-18-7|2,2'-Bipyridine
Introduction：Basic information about CAS 366-18-7|2,2'-Bipyridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2,2'-Bipyridine | ||
|---|---|---|---|
| CAS Number | 366-18-7 | Molecular Weight | 156.184 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 272.5±0.0 °C at 760 mmHg |
| Molecular Formula | C10H8N2 | Melting Point | 70-73 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 107.2±12.0 °C |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | 2,2'-bipyridine |
|---|---|
| Synonym | More Synonyms |
2,2'-Bipyridine BiologicalActivity
| Description | 2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products represented by caerulomycins (CAEs) and collismycins (COLs). 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Others >>Others |
| References | [1]. Chen D, et al. Discovery of caerulomycin/collismycin-type 2,2'-bipyridine natural products in the genomic era. J Ind Microbiol Biotechnol. 2019;46(3-4):459-468. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 272.5±0.0 °C at 760 mmHg |
| Melting Point | 70-73 °C(lit.) |
| Molecular Formula | C10H8N2 |
| Molecular Weight | 156.184 |
| Flash Point | 107.2±12.0 °C |
| Exact Mass | 156.068741 |
| PSA | 25.78000 |
| LogP | 1.28 |
| Vapour Pressure | 0.0±0.5 mmHg at 25°C |
| Index of Refraction | 1.581 |
| InChIKey | ROFVEXUMMXZLPA-UHFFFAOYSA-N |
| SMILES | c1ccc(-c2ccccn2)nc1 |
| Stability | Stable. Incompatible with strong oxidizing agents, most common metals. May be light sensitive. |
| Water Solubility | 5.5 g/L 22 ºC |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Kidney, Ureter, Bladder - other changes in urine composition Blood - hemorrhage
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 131 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 330 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8000 mg/kg/40W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 60 mg/kg
- SEX/DURATION :
- female 12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
MUTATION DATA - TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 14500 ug/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 300,223,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84441 No. of Facilities: 141 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 708 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84441 No. of Facilities: 461 (estimated) No. of Industries: 6 No. of Occupations: 7 No. of Employees: 3684 (estimated) No. of Female Employees: 886 (estimated)
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 14500 ug/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 300,223,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84441 No. of Facilities: 141 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 708 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84441 No. of Facilities: 461 (estimated) No. of Industries: 6 No. of Occupations: 7 No. of Employees: 3684 (estimated) No. of Female Employees: 886 (estimated)
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 |
| Precautionary Statements | P280-P301 + P310-P312 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic |
| Risk Phrases | R25 |
| Safety Phrases | S36/37-S45-S36/37/39-S26 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | DW1750000 |
| Packaging Group | III |
| Hazard Class | 6.1 |
| HS Code | 29333999 |
Customs
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| bipyridine |
| 2-(2-pyridyl)pyridine |
| α,α'-dipyridine |
| EINECS 206-674-4 |
| 2,2’-Bipyridyl |
| dipyridyl |
| 2,2'-Bipyridin |
| 2,2-BIPYRIDINE |
| 2-pyridin-2-ylpyridine |
| 2,2′-bipyridine |
| 2,2′-bipyridyl |
| [2,2]Bipyridinyl |
| α,α'-bipyridine |
| 2,2′ bipyridine |
| 2,2’-bipyridine |
| 2,2'-BIPYRIDINE-3,3'-DIOL |
| 2,2'-Bipyridyl |
| 2,2'-Bipyridine |
| 2,2'-Dipyridyl |
| bipyridyl |
| bpy |
| 2,2‘-Dipyridyl |
| 2,2`-Bipyridyl |
| Dipyridyl, 2,2' |
| MFCD00006212 |
| 2,2′-bipyridinyl |
| 2,2'-dipyridine |
| 2,2-Dipyridyl |
| α,α'-dipyridyl |
| bipy |
| α,α'-Bipyridyl |
