CAS 138949-73-2|Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat) trifluoroac

Introduction：Basic information about CAS 138949-73-2|Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat) trifluoroac, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat) trifluoroacetate salt
CAS Number	138949-73-2	Molecular Weight	619.67
Density	/	Boiling Point	/
Molecular Formula	C₂₇H₄₁N₉O₈	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	thr-arg-ser-ala-trp
Synonym	More Synonyms

BiologicalActivity

Description	Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research[1][2][3][4].
Related Catalog	Signaling Pathways >>Others >>Others
References	[1]. Fenton AJ, et.al. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. Endocrinology. 1991 Dec;129(6):3424-6. [2]. Ibáñez L, et.al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551. [3]. Lozano D, et.al. Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation. Acta Biomater. 2010 Mar;6(3):797-803. [4]. Nácher-Juan J, et.al. Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis. Int J Mol Sci. 2019 Aug 7;20(16):3845.

Description

Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research[1][2][3][4].

Related Catalog

Signaling Pathways >>Others >>Others

References

[1]. Fenton AJ, et.al. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. Endocrinology. 1991 Dec;129(6):3424-6.

[2]. Ibáñez L, et.al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551.

[3]. Lozano D, et.al. Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation. Acta Biomater. 2010 Mar;6(3):797-803.

[4]. Nácher-Juan J, et.al. Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis. Int J Mol Sci. 2019 Aug 7;20(16):3845.

Chemical & Physical Properties

Molecular Formula	C₂₇H₄₁N₉O₈
Molecular Weight	619.67
Exact Mass	619.30800
PSA	297.87000
LogP	0.17260
InChIKey	FFEMNOZDYSNTNO-TWGJCYIBSA-N
SMILES	CC(NC(=O)C(CO)NC(=O)C(CCCN=C(N)N)NC(=O)C(N)C(C)O)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O
Storage condition	-15°C

Synonyms

Osteostain

PARATHYROID HORMONE-RELATED PROTEIN (107-111)

OSTEOSTATIN

MFCD00133747

PTH RELATED PEPTIDE (107-111)

OSTEOSTATIN (HUMAN,RAT)

PTHRP (107-111)

PTH-RP (107-111) (HUMAN,RAT)

PTH-RELATED PROTEIN (107-111) (HUMAN,RAT)

Recommended......