CAS 79360-43-3|Nocloprost

Introduction：Basic information about CAS 79360-43-3|Nocloprost, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Nocloprost BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Nocloprost
CAS Number	79360-43-3	Molecular Weight	400.98000
Density	1.1g/cm3	Boiling Point	539.8ºC at 760 mmHg
Molecular Formula	C₂₂H₃₇ClO₄	Melting Point	/
MSDS	/	Flash Point	280.3ºC

Names

Name	Nocloprost
Synonym	More Synonyms

Nocloprost BiologicalActivity

Description	Nocloprost, a prostaglandin E2 (PGE2) analog, is an orally active EP1- and EP3-receptor agonist. Nocloprost inhibits evoked [3H]ACh release. Nocloprost has gastroprotective and ulcer-healing properties. Nocloprost accelerates the healing of chronic gastric ulcerations and enhances mucosal growth in rats[1][2].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Prostaglandin ReceptorResearch Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic Disease
Target	EP1 EP3
In Vivo	诺氯前列素 (灌胃给药; 0.01-10 μg/kg) 在 100% 乙醇、酸化阿司匹林 (HY-14654)、酸化牛磺胆酸盐 (HY-N0545)、水浸或束缚应激前 30 分钟给药，会剂量依赖性地预防大鼠胃损伤的形成[1]。诺氯前列素 (灌胃给药; 0.01-100 μg/kg) 不会影响胃酸分泌或肠道分泌，但会阻止胃十二指肠碱性分泌增加[1]。诺氯前列素 (皮下给药) 显示出针对乙醇损伤的保护活性，但在十二指肠内应用时无效[1]。 Animal Model: 220-250 g rats[1] Dosage: 0.01-10 μg/kg Administration: Intragastrically; single dose Result: 30 min before 100% ethanol, acidified Aspirin (ASA), acidified Taurocholate, water immersion, or restraint stress dose dependently prevented the formation of gastric lesions, the ID50 values being 0.25, 0.58, 0.06 and 0.12 μg/kg in rats, respectively.
References	[1]. S J Konturek, et al. Nocloprost, a unique prostaglandin E2 analog with local gastroprotective and ulcer-healing activity. Eur J Pharmacol. 1991 Apr 3;195(3):347-57. [2]. T Reinheimer, et al. Prostanoid receptors of the EP3 subtype mediate inhibition of evoked [3H]acetylcholine release from isolated human bronchi. Br J Pharmacol. 1998 Sep;125(2):271-6.

Chemical & Physical Properties

Density	1.1g/cm3
Boiling Point	539.8ºC at 760 mmHg
Molecular Formula	C₂₂H₃₇ClO₄
Molecular Weight	400.98000
Flash Point	280.3ºC
Exact Mass	400.23800
PSA	77.76000
LogP	4.92550
Index of Refraction	1.526
InChIKey	AIOFTOLPMOTZKD-OPVFONCOSA-N
SMILES	CCCCC(C)(C)C(O)C=CC1C(O)CC(Cl)C1CC=CCCCC(=O)O

Synonyms

(5Z,9β,11α,13E,15R)-9-Chloro-11,15-dihydroxy-16,16-dimethylprosta-5,13-dien-1-oic acid

(5Z,9b,11a,13E,15R)-9-Chloro-11,15-dihydroxy-16,16-dimethylprosta-5,13-dien-1-oic Acid

Prosta-5,13-dien-1-oic acid, 9-chloro-11,15-dihydroxy-16,16-dimethyl-, (5Z,9β,11α,13E,15R)-

(5Z,13E)-(9R,11R,15R)-9-chloro-11,15-dihydroxy-16,16-dimethyl-5,13-prostadienoic acid

SH-475

(Z)-7-((1R,2R,3R,5R)-5-Chloro-3-hydroxy-2-((E)-(3R)-3-hydroxy-4,4-dimethyl-1-octenyl)cyclopentyl)-5-heptenoic acid

(Z)-7-[(1R,2R,3R,5R)-5-chloro-2-hydroxy-2-[(E)-(3R)-3-hydroxy-4,4-dimethyl-1-octenyl]cyclopentyl]-5-heptenoic acid

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