CAS 97559-35-8|Neurokinin A(4-10)

Introduction：Basic information about CAS 97559-35-8|Neurokinin A(4-10), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Neurokinin A(4-10) BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Neurokinin A(4-10)
CAS Number	97559-35-8	Molecular Weight	766.90500
Density	1.276g/cm3	Boiling Point	1231.2ºC at 760mmHg
Molecular Formula	C₃₄H₅₄N₈O₁₀S	Melting Point	/
MSDS	/	Flash Point	698.4ºC

Names

Name	neurokinin a (4-10)
Synonym	More Synonyms

Neurokinin A(4-10) BiologicalActivity

Description	Neurokinin A (4-10) is a tachykinin NK2 receptor agonist.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Neurokinin ReceptorSignaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Neurological DiseasePeptides
Target	NK2 receptor[1]
In Vitro	Neurokinin A (NKA) and its truncated form NKA(4-10) are potent spasmogens of human colon circular muscle, an action mediated exclusively via tachykinin NK2 receptors. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) is performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. A high density of NK2 receptors has been demonstrated in this tissue, using in vitro autoradiography and radioligand binding[1].
References	[1]. Warner FJ, et al. Structure-activity relationship of neurokinin A(4-10) at the human tachykinin NK(2) receptor: the effect of amino acid substitutions on receptor affinity and function. Biochem Pharmacol. 2002 Jun 15;63(12):2181-6.

Chemical & Physical Properties

Density	1.276g/cm3
Boiling Point	1231.2ºC at 760mmHg
Molecular Formula	C₃₄H₅₄N₈O₁₀S
Molecular Weight	766.90500
Flash Point	698.4ºC
Exact Mass	766.36800
PSA	326.54000
LogP	1.25010
Index of Refraction	1.565
InChIKey	YLVSTHFZZCHRCL-UHFFFAOYSA-N
SMILES	CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CO)NC(=O)C(N)CC(=O)O)C(C)C)C(N)=O

Synonyms

ASP-SER-PHE-VAL-GLY-LEU-MET-NH2

DSFVGLM-NH2

L-Asp-L-Ser-L-Phe-L-Val-Gly-L-Leu-L-Met-NH2

NKA(4-10)

A-NEUROKININ FRAGMENT 4-10

H-ASP-SER-PHE-VAL-GLY-LEU-MET-NH2

Neurokinin A(4-10)

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